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Down-regulated expression of human leukocyte antigen class I heavy chains is linked to poor prognosis in non-small cell lung cancer

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Please use this identifier to cite or link to this item:http://doi.org/10.14943/doctoral.k12529
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Title: Down-regulated expression of human leukocyte antigen class I heavy chains is linked to poor prognosis in non-small cell lung cancer
Other Titles: 非小細胞肺癌においてHLA Class I H鎖の発現低下は予後不良と相関している
Authors: 市之川, 一臣 Browse this author
Keywords: HLA class I antigen
β2-microglobulin antigen
non-small-cell lung cancer
immunohistochemistry
Issue Date: 23-Mar-2017
Abstract: The aim of this study was to clarify the associations between expression of human leukocyte antigen (HLA) class I on non-small-cell lung cancer (NSCLC) cells, and patient survival. To address this, immunohistochemical staining for HLA class I was performed on specimens from 111 patients with NSCLC, and overall survival curves were compared using the log-rank test. In addition, multivariate analyses were undertaken using Cox's proportional hazard model. The cases were divided into five classes based on expression of HLA class I heavy chain and β2-microglobulin. Overall survival for patients with tumors lacking HLA class I heavy chain (30 cases; 27.0%) was significantly compromised. Multivariate analysis revealed the absence of HLA class I heavy chain to be an independent predictor of poor prognosis. There was a trend towards unfavorable prognosis for those patients whose tumors did not express β2-microglobulin (57 cases; 51.4%). Down-regulation of HLA class I heavy chain expression significantly correlated with down-regulation of β2-microglobulin expression (χ2; 44 p<0.01). Cases lacking both HLA class I heavy chain and β2-microglobulin expression (23 cases; 20.7%) had a statistically significant unfavorable prognosis compared with other cases (p<0.05). Our data demonstrate that lack of HLA class I heavy chain expression in tumor cells is an independent poor prognostic factor for NSCLC survival, and is likely to have an important influence on immune surveillance in patients.
Description: 配架番号:2270
Conffering University: 北海道大学
Degree Report Number: 甲第12529号
Degree Level: 博士
Degree Discipline: 医学
Examination Committee Members: (主査) 教授 松野 吉宏, 教授 秋田 弘俊, 教授 平野 聡
Degree Affiliation: 医学研究科(癌医学専攻)
Type: theses (doctoral)
URI: http://hdl.handle.net/2115/74363
Appears in Collections:課程博士 (Doctorate by way of Advanced Course) > 医学院(Graduate School of Medicine)
学位論文 (Theses) > 博士 (医学)

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