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Down-regulated expression of human leukocyte antigen class I heavy chains is linked to poor prognosis in non-small cell lung cancer
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Title: | Down-regulated expression of human leukocyte antigen class I heavy chains is linked to poor prognosis in non-small cell lung cancer |
Other Titles: | 非小細胞肺癌においてHLA Class I H鎖の発現低下は予後不良と相関している |
Authors: | 市之川, 一臣 Browse this author |
Keywords: | HLA class I antigen | β2-microglobulin antigen | non-small-cell lung cancer | immunohistochemistry |
Issue Date: | 23-Mar-2017 |
Publisher: | Hokkaido University |
Abstract: | The aim of this study was to clarify the associations between expression of human leukocyte antigen (HLA) class I on non-small-cell lung cancer (NSCLC) cells, and patient survival. To address this, immunohistochemical staining for HLA class I was performed on specimens from 111 patients with NSCLC, and overall survival curves were compared using the log-rank test. In addition, multivariate analyses were undertaken using Cox's proportional hazard model. The cases were divided into five classes based on expression of HLA class I heavy chain and β2-microglobulin. Overall survival for patients with tumors lacking HLA class I heavy chain (30 cases; 27.0%) was significantly compromised. Multivariate analysis revealed the absence of HLA class I heavy chain to be an independent predictor of poor prognosis. There was a trend towards unfavorable prognosis for those patients whose tumors did not express β2-microglobulin (57 cases; 51.4%). Down-regulation of HLA class I heavy chain expression significantly correlated with down-regulation of β2-microglobulin expression (χ2; 44 p<0.01). Cases lacking both HLA class I heavy chain and β2-microglobulin expression (23 cases; 20.7%) had a statistically significant unfavorable prognosis compared with other cases (p<0.05). Our data demonstrate that lack of HLA class I heavy chain expression in tumor cells is an independent poor prognostic factor for NSCLC survival, and is likely to have an important influence on immune surveillance in patients. |
Description: | 配架番号:2270 |
Conffering University: | 北海道大学 |
Degree Report Number: | 甲第12529号 |
Degree Level: | 博士 |
Degree Discipline: | 医学 |
Examination Committee Members: | (主査) 教授 松野 吉宏, 教授 秋田 弘俊, 教授 平野 聡 |
Degree Affiliation: | 医学研究科(癌医学専攻) |
Type: | theses (doctoral) |
URI: | http://hdl.handle.net/2115/74363 |
Appears in Collections: | 課程博士 (Doctorate by way of Advanced Course) > 医学院(Graduate School of Medicine) 学位論文 (Theses) > 博士 (医学)
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