HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Hokkaido University Hospital >
Peer-reviewed Journal Articles, etc >

Regulatory T cells in autoimmune skin diseases

Files in This Item:

The file(s) associated with this item can be obtained from the following URL:

Title: Regulatory T cells in autoimmune skin diseases
Authors: Ujiie, Hideyuki Browse this author →KAKEN DB
Keywords: alopecia areata
systemic sclerosis
Issue Date: Jun-2019
Publisher: John Wiley & Sons
Journal Title: Experimental dermatology
Volume: 28
Issue: 6
Start Page: 642
End Page: 646
Publisher DOI: 10.1111/exd.13535
PMID: 29575350
Abstract: CD4(+)Foxp3(+) regulatory T cells (Tregs) are suppressors of immune activation and play a crucial role in the maintenance of peripheral tolerance. Mutations of Foxp3 result in fatal autoimmunity in multiple organs, including the skin, in both humans and mice. Many studies have demonstrated the altered frequency and functions of Tregs, changes in cytokine and chemokine levels related to Tregs and the differences in genetic background regarding Tregs in autoimmune skin disorders. Recent studies have extended our knowledge of certain properties of Tregs, especially skin-resident Tregs. In addition, some novel therapies have been performed by modulating the number and the function of Tregs. This review focuses on the role of Tregs in some autoimmune skin disorders, including alopecia areata, vitiligo, pemphigoid and pemphigus, and systemic sclerosis, and discusses questions that remain to be addressed.
Type: article
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Export metadata:

OAI-PMH ( junii2 , jpcoar )

MathJax is now OFF:


 - Hokkaido University