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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Dental Medicine / Faculty of Dental Medicine >
Peer-reviewed Journal Articles, etc >
Human Dentin Coated with Silver Nanoclusters Exhibits Antibacterial Activity against Streptococcus mutans
| Title: | Human Dentin Coated with Silver Nanoclusters Exhibits Antibacterial Activity against Streptococcus mutans |
| Authors: | SHITOMI, Kanako Browse this author | | MIYAJI, Hirofumi Browse this author →KAKEN DB | | MIYATA, Saori Browse this author | | NISHIDA, Erika Browse this author →KAKEN DB | | MAYUMI, Kayoko Browse this author | | SUGAYA, Tsutomu Browse this author →KAKEN DB | | KAWASAKI, Hideya Browse this author →KAKEN DB |
| Keywords: | antibacterial effect | | human dentin | | silver nanoclusters (AgNCs) | | streptococcus mutans |
| Issue Date: | 4-Aug-2019 |
| Publisher: | ナノ・バイオメディカル学会 |
| Journal Title: | Nano Biomedicine |
| Volume: | 11 |
| Issue: | 1 |
| Start Page: | 21 |
| End Page: | 28 |
| Publisher DOI: | 10.11344/nano.11.21 |
| Abstract: | Silver nanoclusters (AgNCs) are ultrasmall in size (< 2 nm) and are expected to be an effective antibacterial substance to combat oral infective diseases. In the present study, we synthesized AgNCs (Ag∼75) as the main component for esthetic and antibacterial application against the caries pathogen Streptococcus mutans. The results showed that AgNCs significantly reduced the turbidity and viability of S. mutans. In addition, the bactericidal effects of AgNCs were confirmed by LIVE/DEAD staining. After AgNC application to human dentin, no discoloration of dentin was observed, as compared to silver diamine fluoride application, and AgNC-treated dentin showed an inhibitory effect on colony formation by S. mutans. Therefore, AgNCs appear to be beneficial for dental therapy as an antibacterial and/or esthetic substrate. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/75224 |
| Appears in Collections: | 歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 宮治 裕史
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