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Human Dentin Coated with Silver Nanoclusters Exhibits Antibacterial Activity against Streptococcus mutans

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/75224

Title: Human Dentin Coated with Silver Nanoclusters Exhibits Antibacterial Activity against Streptococcus mutans
Authors: SHITOMI, Kanako Browse this author
MIYAJI, Hirofumi Browse this author →KAKEN DB
MIYATA, Saori Browse this author
NISHIDA, Erika Browse this author →KAKEN DB
MAYUMI, Kayoko Browse this author
SUGAYA, Tsutomu Browse this author →KAKEN DB
KAWASAKI, Hideya Browse this author →KAKEN DB
Keywords: antibacterial effect
human dentin
silver nanoclusters (AgNCs)
streptococcus mutans
Issue Date: 4-Aug-2019
Publisher: ナノ・バイオメディカル学会
Journal Title: Nano Biomedicine
Volume: 11
Issue: 1
Start Page: 21
End Page: 28
Publisher DOI: 10.11344/nano.11.21
Abstract: Silver nanoclusters (AgNCs) are ultrasmall in size (< 2 nm) and are expected to be an effective antibacterial substance to combat oral infective diseases. In the present study, we synthesized AgNCs (Ag∼75) as the main component for esthetic and antibacterial application against the caries pathogen Streptococcus mutans. The results showed that AgNCs significantly reduced the turbidity and viability of S. mutans. In addition, the bactericidal effects of AgNCs were confirmed by LIVE/DEAD staining. After AgNC application to human dentin, no discoloration of dentin was observed, as compared to silver diamine fluoride application, and AgNC-treated dentin showed an inhibitory effect on colony formation by S. mutans. Therefore, AgNCs appear to be beneficial for dental therapy as an antibacterial and/or esthetic substrate.
Type: article
URI: http://hdl.handle.net/2115/75224
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 宮治 裕史

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