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Long-term follow-up after proton beam therapy for pediatric tumors: a Japanese national survey

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Title: Long-term follow-up after proton beam therapy for pediatric tumors: a Japanese national survey
Authors: Mizumoto, Masashi Browse this author →KAKEN DB
Murayama, Shigeyuki Browse this author →KAKEN DB
Akimoto, Tetsuo Browse this author →KAKEN DB
Demizu, Yusuke Browse this author
Fukushima, Takashi Browse this author
Ishida, Yuji Browse this author
Oshiro, Yoshiko Browse this author →KAKEN DB
Numajiri, Haruko Browse this author →KAKEN DB
Fuji, Hiroshi Browse this author →KAKEN DB
Okumura, Toshiyuki Browse this author →KAKEN DB
Shirato, Hiroki Browse this author →KAKEN DB
Hideyuki, Sakurai Browse this author →KAKEN DB
Keywords: Late toxicity
Secondary cancer
Issue Date: Mar-2017
Publisher: Wiley
Japanese Cancer Association
Journal Title: Cancer Science
Volume: 108
Issue: 3
Start Page: 444
End Page: 447
Publisher DOI: 10.1111/cas.13140
PMID: 28004469
Abstract: Proton beam therapy (PBT) is a potential new alternative to treatment with photon radiotherapy that may reduce the risk of late toxicity and secondary cancer, especially for pediatric tumors. The goal of this study was to evaluate the long‐term benefits of PBT in cancer survivors. A retrospective observational study of pediatric patients who received PBT was performed at four institutions in Japan. Of 343 patients, 62 were followed up for 5 or more years. These patients included 40 males and 22 females, and had a median age of 10 years (range: 0–19 years) at the time of treatment. The irradiation dose ranged from 10.8 to 81.2 GyE (median: 50.4 GyE). The median follow‐up period was 8.1 years (5.0–31.2 years). The 5‐, 10‐ and 20‐year rates for grade 2 or higher late toxicities were 18%, 35% and 45%, respectively, and those for grade 3 or higher late toxicities were 6%, 17% and 17% respectively. Univariate analysis showed that the irradiated site (head and neck, brain) was significantly associated with late toxicities. No malignant secondary tumors occurred within the irradiated field. The 10‐ and 20‐year cumulative rates for all secondary tumors, malignant secondary tumors, and malignant nonhematologic secondary tumors were 8% and 16%, 5% and 13%, and 3% and 11%, respectively. Our data indicate that PBT has the potential to reduce the risk of late mortality and secondary malignancy. Longer follow‐up is needed to confirm the benefits of PBT for pediatric tumors.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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