|
|
Hokkaido University Collection of Scholarly and Academic Papers >
Global Institution for Collaborative Research and Education : GI-CoRE >
Peer-reviewed Journal Articles, etc >
Long-term follow-up after proton beam therapy for pediatric tumors: a Japanese national survey
This item is licensed under:Creative Commons Attribution-NonCommercial 4.0 International
| Title: | Long-term follow-up after proton beam therapy for pediatric tumors: a Japanese national survey |
| Authors: | Mizumoto, Masashi Browse this author →KAKEN DB | | Murayama, Shigeyuki Browse this author →KAKEN DB | | Akimoto, Tetsuo Browse this author →KAKEN DB | | Demizu, Yusuke Browse this author | | Fukushima, Takashi Browse this author | | Ishida, Yuji Browse this author | | Oshiro, Yoshiko Browse this author →KAKEN DB | | Numajiri, Haruko Browse this author →KAKEN DB | | Fuji, Hiroshi Browse this author →KAKEN DB | | Okumura, Toshiyuki Browse this author →KAKEN DB | | Shirato, Hiroki Browse this author →KAKEN DB | | Hideyuki, Sakurai Browse this author →KAKEN DB |
| Keywords: | Late toxicity | | Pediatrics | | Proton | | Radiotherapy | | Secondary cancer |
| Issue Date: | Mar-2017 |
| Publisher: | Wiley | | Japanese Cancer Association |
| Journal Title: | Cancer Science |
| Volume: | 108 |
| Issue: | 3 |
| Start Page: | 444 |
| End Page: | 447 |
| Publisher DOI: | 10.1111/cas.13140 |
| PMID: | 28004469 |
| Abstract: | Proton beam therapy (PBT) is a potential new alternative to treatment with photon radiotherapy that may reduce the risk of late toxicity and secondary cancer, especially for pediatric tumors. The goal of this study was to evaluate the long‐term benefits of PBT in cancer survivors. A retrospective observational study of pediatric patients who received PBT was performed at four institutions in Japan. Of 343 patients, 62 were followed up for 5 or more years. These patients included 40 males and 22 females, and had a median age of 10 years (range: 0–19 years) at the time of treatment. The irradiation dose ranged from 10.8 to 81.2 GyE (median: 50.4 GyE). The median follow‐up period was 8.1 years (5.0–31.2 years). The 5‐, 10‐ and 20‐year rates for grade 2 or higher late toxicities were 18%, 35% and 45%, respectively, and those for grade 3 or higher late toxicities were 6%, 17% and 17% respectively. Univariate analysis showed that the irradiated site (head and neck, brain) was significantly associated with late toxicities. No malignant secondary tumors occurred within the irradiated field. The 10‐ and 20‐year cumulative rates for all secondary tumors, malignant secondary tumors, and malignant nonhematologic secondary tumors were 8% and 16%, 5% and 13%, and 3% and 11%, respectively. Our data indicate that PBT has the potential to reduce the risk of late mortality and secondary malignancy. Longer follow‐up is needed to confirm the benefits of PBT for pediatric tumors. |
| Rights: | https://creativecommons.org/licenses/by-nc/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/75506 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
|
