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Prognoses and Clinicopathological Characteristics for Hepatocellular Carcinoma Originating from the Caudate Lobe After Surgery

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Title: Prognoses and Clinicopathological Characteristics for Hepatocellular Carcinoma Originating from the Caudate Lobe After Surgery
Authors: Shimada, Shingo Browse this author
Kamiyama, Toshiya Browse this author →KAKEN DB
Yokoo, Hideki Browse this author →KAKEN DB
Orimo, Tatsuya Browse this author
Nagatsu, Akihisa Browse this author
Ohata, Takanori Browse this author
Kamachi, Hirofumi Browse this author →KAKEN DB
Taketomi, Akinobu Browse this author →KAKEN DB
Keywords: hepatocellular carcinoma
caudate lobe
portal invasion
Issue Date: Apr-2019
Publisher: Springer
Journal Title: World journal of surgery
Volume: 43
Issue: 4
Start Page: 1085
End Page: 1093
Publisher DOI: 10.1007/s00268-018-4869-2
Abstract: BackgroundThe aim was to evaluate the prognoses and clinicopathological characteristics of solitary hepatocellular carcinoma (HCC) originating from the caudate lobe (HCC-CL).MethodsWe analyzed 584 patients with a solitary tumor <10cm from January 1990 to November 2014. Patients were classified into a caudate lobe group (CL; n=39) and a non-caudate lobe group (NCL; n=545). We investigated the prognoses and clinicopathological characteristics of solitary HCC-CL. We compared the surgical procedures performed in these cases.ResultsHCC-CL had a similar rate of portal venous invasion (PVI) as HCC-NCL (21% vs. 19%); however, the frequency of tumor thrombus at the first branch of the portal vein (PV) or extension to the trunk or the opposite side of the PV was significantly higher in HCC-CL (8% vs. 2%). HCC-CL had similar OS rates compared to HCC-NCL; however, HCC-CL showed significantly poorer RFS. Although there were no significant differences among the three surgical procedures, blood loss and complication rates tended to be higher in cases who underwent an isolated caudate lobectomy. Tumor size 5cm, PVI, and liver fibrosis or cirrhosis (LF or LC) were independent unfavorable factors for both OS and RFS. PIVKA-II 120mAU/ml was an independent unfavorable factor for RFS.ConclusionHCC-CL presented a poorer RFS rate. Patients with a tumor size 5cm, PIVKA-II 120mAU/ml, portal venous invasion, and LF or LC should be diligently followed up as these cases have a high risk of recurrence.
Rights: The original publication is available at www.springerlink.com
Type: article (author version)
URI: http://hdl.handle.net/2115/77188
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 神山 俊哉

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