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Copper-catalyzed enantioselective conjugate reduction of alpha,beta-unsaturated esters with chiral phenol-carbene ligands

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Title: Copper-catalyzed enantioselective conjugate reduction of alpha,beta-unsaturated esters with chiral phenol-carbene ligands
Authors: Mimura, Shohei Browse this author
Mizushima, Sho Browse this author
Shimizu, Yohei Browse this author
Sawamura, Masaya Browse this author →KAKEN DB
Keywords: catalyst
chiral NHC
conjugate reduction
copper catalysis
enantioselective reaction
Issue Date: 31-Mar-2020
Publisher: Beilstein-Institut
Journal Title: Beilstein journal of organic chemistry
Volume: 16
Start Page: 537
End Page: 543
Publisher DOI: 10.3762/bjoc.16.50
Abstract: A chiral phenol-NHC ligand enabled the copper-catalyzed enantioselective conjugate reduction of alpha,beta-unsaturated esters. The phenol moiety of the chiral NHC ligand played a critical role in producing the enantiomerically enriched products. The catalyst worked well for various (Z)-isomer substrates. Opposite enantiomers were obtained from (Z)- and (E)-isomers, with a higher enantiomeric excess from the (Z)-isomer.
Rights: http://creativecommons.org/licenses/by/4.0
Type: article
URI: http://hdl.handle.net/2115/78345
Appears in Collections:理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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