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Supernormal Antithrombin Activity Is an Independent Predictor of In-Hospital Mortality in Patients With Sepsis : A Retrospective Observational Study

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Title: Supernormal Antithrombin Activity Is an Independent Predictor of In-Hospital Mortality in Patients With Sepsis : A Retrospective Observational Study
Authors: Azuhata, Takeo Browse this author
Hayakwa, Mineji Browse this author
Maekawa, Kunihiko Browse this author
Komatsu, Tomohide Browse this author
Kuwana, Tsukasa Browse this author
Kawano, Daisuke Browse this author
Nakamura, Kazuhiro Browse this author
Kinoshita, Kosaku Browse this author →KAKEN DB
Wada, Takeshi Browse this author →KAKEN DB
Tanjoh, Katsuhisa Browse this author
Keywords: antithrombin
disseminated intravascular coagulation
mortality
prognosis
sepsis
Issue Date: 10-Apr-2020
Publisher: SAGE Publications
Journal Title: Clinical and applied thrombosis/hemostasis
Volume: 26
Start Page: UNSP 1076029620912827
Publisher DOI: 10.1177/1076029620912827
Abstract: Supernormal antithrombin (AT) activity is rare in patients with sepsis. This study compared mortality rate of patients with sepsis and supernormal AT activity with that of other patients. This retrospective study included patients with sepsis from 42 intensive care units (ICUs) in Japan. Patients were included if their AT activity was measured on ICU admission, and if they did not receive AT concentrate. They were categorized into low, normal, and supernormal with respective AT activity of <= 70%, >70% to <= 100%, and >100%. The primary outcome was hospital in-patient mortality. Nonlinear regression analysis showed that mortality risk gradually increased with AT activity in the supernormal range, but without statistical significance. Survival rate was significantly lower in low (67%) and supernormal (57%) AT groups than in the normal AT group (79%; P < .001 and P = .008, respectively). After adjusting for disease severity and AT activity on day 2, supernormal AT activity was the only independent predictor of mortality. Sepsis with supernormal AT activity associated with high mortality, independent of disease severity, might be a predictor of in-hospital mortality.
Rights: https://creativecommons.org/licenses/by-nc/4.0/
Type: article
URI: http://hdl.handle.net/2115/78419
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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