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Serotonin Syndrome Developing Immediately after the Initiation of Low-Dose Methadone Therapy : A Case Report
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| Title: | Serotonin Syndrome Developing Immediately after the Initiation of Low-Dose Methadone Therapy : A Case Report |
| Authors: | Kumai, Masayoshi Browse this author | | Maeda, Yosuke Browse this author | | Miura, Mototsugu Browse this author | | Tsuruga, Kenkichi Browse this author | | Yamada, Takehiro Browse this author | | Takekuma, Yoh Browse this author →KAKEN DB | | Sugawara, Mitsuru Browse this author →KAKEN DB |
| Keywords: | Serotonin syndrome | | Methadone | | Oxycodone |
| Issue Date: | Jan-2020 |
| Publisher: | Karger |
| Journal Title: | Case reports in oncology |
| Volume: | 13 |
| Issue: | 1 |
| Start Page: | 281 |
| End Page: | 284 |
| Publisher DOI: | 10.1159/000506443 |
| Abstract: | We present a case in which serotonin syndrome developed immediately after the initiation of low-dose methadone following an increase in oxycodone dose and the initiation of duloxetine. The symptoms of serotonin syndrome were alleviated and later disappeared upon cessation of methadone alone. The case was a 47-year-old woman with a desmoid tumor. The administration of duloxetine (20 mg/day) was initiated while the patient took oxycodone sustained-release tablets (40 mg/day). The following day, excessive perspiration, chills, and tremors appeared after the initiation of 15 mg/day methadone. Discontinuation of methadone led to an alleviation of the symptoms which completely disappeared 3 days later. The results suggest that low-dose methadone can trigger serotonin syndrome as early as after the first dose. Thus, it is important to be aware of the risks and to immediately take action if symptoms appear. |
| Rights: | The final, published version of this article is available at http://www.karger.com/?doi=10.1159/000506443 | | https://creativecommons.org/licenses/by-nc/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/78559 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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