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Serotonin Syndrome Developing Immediately after the Initiation of Low-Dose Methadone Therapy : A Case Report

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Title: Serotonin Syndrome Developing Immediately after the Initiation of Low-Dose Methadone Therapy : A Case Report
Authors: Kumai, Masayoshi Browse this author
Maeda, Yosuke Browse this author
Miura, Mototsugu Browse this author
Tsuruga, Kenkichi Browse this author
Yamada, Takehiro Browse this author
Takekuma, Yoh Browse this author →KAKEN DB
Sugawara, Mitsuru Browse this author →KAKEN DB
Keywords: Serotonin syndrome
Issue Date: Jan-2020
Publisher: Karger
Journal Title: Case reports in oncology
Volume: 13
Issue: 1
Start Page: 281
End Page: 284
Publisher DOI: 10.1159/000506443
Abstract: We present a case in which serotonin syndrome developed immediately after the initiation of low-dose methadone following an increase in oxycodone dose and the initiation of duloxetine. The symptoms of serotonin syndrome were alleviated and later disappeared upon cessation of methadone alone. The case was a 47-year-old woman with a desmoid tumor. The administration of duloxetine (20 mg/day) was initiated while the patient took oxycodone sustained-release tablets (40 mg/day). The following day, excessive perspiration, chills, and tremors appeared after the initiation of 15 mg/day methadone. Discontinuation of methadone led to an alleviation of the symptoms which completely disappeared 3 days later. The results suggest that low-dose methadone can trigger serotonin syndrome as early as after the first dose. Thus, it is important to be aware of the risks and to immediately take action if symptoms appear.
Rights: The final, published version of this article is available at
Type: article
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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