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Inverse correlation between serum high‐molecular‐weight adiponectin and proinsulin level in a Japanese population : the DOSANCO Health Study
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Title: | Inverse correlation between serum high‐molecular‐weight adiponectin and proinsulin level in a Japanese population : the DOSANCO Health Study |
Authors: | Nakamura, Akinobu Browse this author →KAKEN DB | Miyoshi, Hideaki Browse this author →KAKEN DB | Ukawa, Shigekazu Browse this author →KAKEN DB | Nakamura, Koshi Browse this author →KAKEN DB | Nakagawa, Takafumi Browse this author | Terauchi, Yasuo Browse this author →KAKEN DB | Tamakoshi, Akiko Browse this author →KAKEN DB | Atsumi, Tatsuya Browse this author →KAKEN DB |
Keywords: | adiponectin | pancreatic beta-cells | proinsulin |
Issue Date: | Jan-2021 |
Publisher: | John Wiley & Sons |
Journal Title: | Journal of Diabetes Investigation |
Volume: | 12 |
Issue: | 1 |
Start Page: | 63 |
End Page: | 66 |
Publisher DOI: | 10.1111/jdi.13323 |
Abstract: | Serum high‐molecular‐weight adiponectin (HMWA) has a positive correlation with insulin secretion in a Japanese population. To validate this correlation, we investigated the correlation between serum HMWA and proinsulin, a marker of beta‐cell dysfunction, in this population. 488 participants (53.9% females) aged 35 to 79 years without having oral hypoglycemic agents and/or insulin were enrolled. HMWA was significantly and inversely correlated with proinsulin adjusted for age and sex (partial regression coefficient: β= -0.37; 95% confidence interval: -0.46 to -0.28). When the participants were divided into two groups by median values of body mass index (23.2 kg/m2), serum insulin (4.3 μU/mL), or homeostasis model assessment of insulin resistance (1.0), similar inverse correlations were observed adjusted for age and sex in both groups. Our results demonstrated that the HMWA level was inversely correlated with the proinsulin level in a general Japanese population. |
Rights: | http://creativecommons.org/licenses/by/4.0/ |
Type: | article |
URI: | http://hdl.handle.net/2115/80120 |
Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 三好 秀明
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