HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >

Inverse correlation between serum high‐molecular‐weight adiponectin and proinsulin level in a Japanese population : the DOSANCO Health Study

This item is licensed under: Creative Commons Attribution 4.0 International

Files in This Item:
jdi.13323.pdf262.88 kBPDFView/Open
Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/80120

Title: Inverse correlation between serum high‐molecular‐weight adiponectin and proinsulin level in a Japanese population : the DOSANCO Health Study
Authors: Nakamura, Akinobu Browse this author →KAKEN DB
Miyoshi, Hideaki Browse this author →KAKEN DB
Ukawa, Shigekazu Browse this author →KAKEN DB
Nakamura, Koshi Browse this author →KAKEN DB
Nakagawa, Takafumi Browse this author
Terauchi, Yasuo Browse this author →KAKEN DB
Tamakoshi, Akiko Browse this author →KAKEN DB
Atsumi, Tatsuya Browse this author →KAKEN DB
Keywords: adiponectin
pancreatic beta-cells
proinsulin
Issue Date: Jan-2021
Publisher: John Wiley & Sons
Journal Title: Journal of Diabetes Investigation
Volume: 12
Issue: 1
Start Page: 63
End Page: 66
Publisher DOI: 10.1111/jdi.13323
Abstract: Serum high‐molecular‐weight adiponectin (HMWA) has a positive correlation with insulin secretion in a Japanese population. To validate this correlation, we investigated the correlation between serum HMWA and proinsulin, a marker of beta‐cell dysfunction, in this population. 488 participants (53.9% females) aged 35 to 79 years without having oral hypoglycemic agents and/or insulin were enrolled. HMWA was significantly and inversely correlated with proinsulin adjusted for age and sex (partial regression coefficient: β= -0.37; 95% confidence interval: -0.46 to -0.28). When the participants were divided into two groups by median values of body mass index (23.2 kg/m2), serum insulin (4.3 μU/mL), or homeostasis model assessment of insulin resistance (1.0), similar inverse correlations were observed adjusted for age and sex in both groups. Our results demonstrated that the HMWA level was inversely correlated with the proinsulin level in a general Japanese population.
Rights: http://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/80120
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 三好 秀明

Export metadata:

OAI-PMH ( junii2 , jpcoar_1.0 )

MathJax is now OFF:


 

 - Hokkaido University