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Molecular characterization of a Newcastle disease virus isolate from a diseased chicken in the Philippines in 2017

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Title: Molecular characterization of a Newcastle disease virus isolate from a diseased chicken in the Philippines in 2017
Authors: Tran, Giang Thi Huong Browse this author
Mananggit, Milagros Reyes Browse this author
Abao, Lary Nel Bilbao Browse this author
Dong, Hieu Van Browse this author
Takeda, Yohei Browse this author →KAKEN DB
Ogawa, Haruko Browse this author →KAKEN DB
Imai, Kunitoshi Browse this author →KAKEN DB
Keywords: Genotype VII
Newcastle disease virus
The Philippines
Issue Date: Feb-2021
Publisher: Faculty of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 69
Issue: 1
Start Page: 73
End Page: 81
Abstract: Newcastle disease (ND) is one of the most serious diseases affecting numerous avian species worldwide. However, data on the genetic characterization of ND virus (NDV) in the Philippines are limited. Herein, the complete sequences of the fusion (F) and hemagglutinin-neuraminidase (HN) genes of a NDV strain isolated in Central Luzon in 2017 were genetically analyzed. The results revealed that the field isolate belonged to subgenotype VII.2 and the genome encoded the amino acid sequence of the F0 protein proteolytic cleavage site motif (112R-R-Q-K-R-F117), indicating that it was a virulent strain. The current NDV strain was genetically related to Indonesian and Israeli NDV strains. Some amino acid substitutions were found in the transmembrane domain and neutralizing epitopes of the HN protein.
Type: bulletin (article)
Appears in Collections:Japanese Journal of Veterinary Research > Volume 69 Number 1

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