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A New Variant among Newcastle Disease Viruses Isolated in the Democratic Republic of the Congo in 2018 and 2019

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Title: A New Variant among Newcastle Disease Viruses Isolated in the Democratic Republic of the Congo in 2018 and 2019
Authors: Twabela, Augustin T. Browse this author
Lam, Thanh Nguyen Browse this author
Masumu, Justin Browse this author
Mpoyo, Patrick Browse this author
Mpiana, Serge Browse this author
Sumbu, Julienne Browse this author
Okamatsu, Masatoshi Browse this author →KAKEN DB
Matsuno, Keita Browse this author →KAKEN DB
Isoda, Norikazu Browse this author →KAKEN DB
Zecchin, Bianca Browse this author
Monne, Isabella Browse this author
Sakoda, Yoshihiro Browse this author →KAKEN DB
Keywords: new variant
Newcastle disease virus
chicken outbreak
Democratic Republic of the Congo
Issue Date: Feb-2021
Publisher: MDPI
Journal Title: Viruses-Basel
Volume: 13
Issue: 2
Start Page: 151
Publisher DOI: 10.3390/v13020151
Abstract: Newcastle disease (ND) is a highly transmissible and devastating disease that affects poultry and wild birds worldwide. Comprehensive knowledge regarding the characteristics and epidemiological factors of the ND virus (NDV) is critical for the control and prevention of ND. Effective vaccinations can prevent and control the spread of the NDV in poultry populations. For decades, the Democratic Republic of the Congo (DRC) has reported the impacts of ND on commercial and traditional poultry farming systems. The reports were preliminary clinical observations, and few cases were confirmed in the laboratory. However, data on the phylogenetic, genetic, and virological characteristics of NDVs circulating in the DRC are not available. In this study, the whole-genome sequences of three NDV isolates obtained using the next-generation sequencing method revealed two isolates that were a new variant of NDV, and one isolate that was clustered in the subgenotype VII.2. All DRC isolates were velogenic and were antigenically closely related to the vaccine strains. Our findings reveal that despite the circulation of the new variant, ND can be controlled in the DRC using the current vaccine. However, epidemiological studies should be conducted to elucidate the endemicity of the disease so that better control strategies can be implemented.
Type: article
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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