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Study on chemical compounds for the development of anti-ebolavirus drugs [an abstract of entire text]
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| Title: | Study on chemical compounds for the development of anti-ebolavirus drugs [an abstract of entire text] |
| Other Titles: | 抗エボラウイルス薬開発に向けた化合物の探索 [全文の要約] |
| Authors: | 磯野, 真央 Browse this author |
| Issue Date: | 25-Mar-2021 |
| Publisher: | Hokkaido University |
| Abstract: | Following the EVD outbreaks in Africa, there has been an increased necessity of effective therapies against EBOV. Several candidate drugs have been clinically tested until now but an antibody therapy has only been approved by FDA in 2020. Thus, more treatment options including chemical compound-based drugs for EVD are needed. This chapter focuses on chemical compounds for the development of anti-EBOV drugs, especially inhibitors of viral genome transcription/replication and budding. I screened a chemical compound library from ITbM and discovered several compounds that inhibited the EBOV minigenome-derived luciferase activity and/or the egress of virions. Here I discuss that EBOV replication and budding steps are good targets for therapeutic agents although such drugs have never been approved yet. Candidate compounds that were discovered in this study are expected to provide novel perspectives for the development of anti-EBOV drugs in the future. |
| Description: | この博士論文全文の閲覧方法については、以下のサイトをご参照ください。 |
| Description URI: | https://www.lib.hokudai.ac.jp/dissertations/copy-guides/ |
| Conffering University: | 北海道大学 |
| Degree Report Number: | 甲第14550号 |
| Degree Level: | 博士 |
| Degree Discipline: | 感染症学 |
| Examination Committee Members: | (主査) 教授 東 秀明, 教授 髙田 礼人, 教授 苅和 宏明, 教授 迫田 義博 |
| Degree Affiliation: | 国際感染症学院（感染症学専攻） |
| Type: | theses (doctoral - abstract of entire text) |
| URI: | http://hdl.handle.net/2115/81948 |
| Appears in Collections: | 課程博士 (Doctorate by way of Advanced Course) > 国際感染症学院(Graduate School of Infectious Diseases)
学位論文 (Theses) > 博士 （感染症学）
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