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Simultaneous T-2* mapping of N-14- and N-15-labeled dicarboxy-PROXYLs using CW-EPR-based single-point imaging
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Title: | Simultaneous T-2* mapping of N-14- and N-15-labeled dicarboxy-PROXYLs using CW-EPR-based single-point imaging |
Authors: | Yokoyama, Takahito Browse this author | Taguchi, Akihiro Browse this author | Kubota, Harue Browse this author | Stewart, Neil J. Browse this author | Matsumoto, Shingo Browse this author →KAKEN DB | Kirilyuk, Igor A. Browse this author | Hirata, Hiroshi Browse this author →KAKEN DB |
Keywords: | EPR | T-2* mapping | Nitroxyl radical | Single-point imaging | Gradient-descent optimization | Oxygenation |
Issue Date: | Aug-2019 |
Publisher: | Elsevier |
Journal Title: | Journal of magnetic resonance |
Volume: | 305 |
Start Page: | 122 |
End Page: | 130 |
Publisher DOI: | 10.1016/j.jmr.2019.06.012 |
Abstract: | This article reports a method of simultaneous T-2* mapping of N-14- and N-15-labeled dicarboxy-PROXYLs using 750-MHz continuous-wave electron paramagnetic resonance (CW-EPR) imaging. To separate the spectra of N-14- and N-15-labeled dicarboxy-PROXYLs under magnetic field gradients, an optimization problem for spectral projections was formulated with the spatial total variation as a regularization term and solved using a local search based on the gradient descent algorithm. Using the single-point imaging (SPI) method with spectral projections of each radical, simultaneous T-2* mapping was performed for solution samples. Simultaneous T-2* mapping enabled visualization of the response of T-2* values to the level of dissolved oxygen in the solution. Simultaneous T-2* mapping applied to a mouse tumor model demonstrated the feasibility of the reported method for potential application to in vivo oxygenation imaging. (C) 2019 Elsevier Inc. All rights reserved. |
Rights: | ©2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/82322 |
Appears in Collections: | 情報科学院・情報科学研究院 (Graduate School of Information Science and Technology / Faculty of Information Science and Technology) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 平田 拓
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