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Simultaneous T-2* mapping of N-14- and N-15-labeled dicarboxy-PROXYLs using CW-EPR-based single-point imaging

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Title: Simultaneous T-2* mapping of N-14- and N-15-labeled dicarboxy-PROXYLs using CW-EPR-based single-point imaging
Authors: Yokoyama, Takahito Browse this author
Taguchi, Akihiro Browse this author
Kubota, Harue Browse this author
Stewart, Neil J. Browse this author
Matsumoto, Shingo Browse this author →KAKEN DB
Kirilyuk, Igor A. Browse this author
Hirata, Hiroshi Browse this author →KAKEN DB
Keywords: EPR
T-2* mapping
Nitroxyl radical
Single-point imaging
Gradient-descent optimization
Oxygenation
Issue Date: Aug-2019
Publisher: Elsevier
Journal Title: Journal of magnetic resonance
Volume: 305
Start Page: 122
End Page: 130
Publisher DOI: 10.1016/j.jmr.2019.06.012
Abstract: This article reports a method of simultaneous T-2* mapping of N-14- and N-15-labeled dicarboxy-PROXYLs using 750-MHz continuous-wave electron paramagnetic resonance (CW-EPR) imaging. To separate the spectra of N-14- and N-15-labeled dicarboxy-PROXYLs under magnetic field gradients, an optimization problem for spectral projections was formulated with the spatial total variation as a regularization term and solved using a local search based on the gradient descent algorithm. Using the single-point imaging (SPI) method with spectral projections of each radical, simultaneous T-2* mapping was performed for solution samples. Simultaneous T-2* mapping enabled visualization of the response of T-2* values to the level of dissolved oxygen in the solution. Simultaneous T-2* mapping applied to a mouse tumor model demonstrated the feasibility of the reported method for potential application to in vivo oxygenation imaging. (C) 2019 Elsevier Inc. All rights reserved.
Rights: ©2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/82322
Appears in Collections:情報科学院・情報科学研究院 (Graduate School of Information Science and Technology / Faculty of Information Science and Technology) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 平田 拓

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