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Simultaneous external validation of various cardiac arrest prognostic scores: a single-center retrospective study

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Title: Simultaneous external validation of various cardiac arrest prognostic scores: a single-center retrospective study
Authors: Tsuchida, Takumi Browse this author
Ono, Kota Browse this author
Maekawa, Kunihiko Browse this author
Wada, Takeshi Browse this author
Katabami, Kenichi Browse this author
Yoshida, Tomonao Browse this author
Hayakawa, Mineji Browse this author →KAKEN DB
Keywords: Out-of-hospital cardiac arrest
Neurological outcome
Issue Date: 14-Aug-2021
Publisher: BioMed Central
Journal Title: Scandinavian Journal of Trauma Resuscitation and Emergency Medicine
Volume: 29
Issue: 1
Start Page: 117
Publisher DOI: 10.1186/s13049-021-00935-w
Abstract: Background This study aimed to compare and validate the out-of-hospital cardiac arrest (OHCA); cardiac arrest hospital prognosis (CAHP); non-shockable rhythm, unwitnessed arrest, long no-flow or long low-flow period, blood pH < 7.2, lactate > 7.0 mmol/L, end-stage chronic kidney disease, age >= 85 years, still resuscitation, and extracardiac cause (NULL-PLEASE) clinical; post-cardiac arrest syndrome for therapeutic hypothermia (CAST); and revised CAST (rCAST) scores in OHCA patients treated with recent cardiopulmonary resuscitation strategies. Methods We retrospectively collected data on adult OHCA patients admitted to our emergency department between February 2015 and July 2018. OHCA, CAHP, NULL-PLEASE clinical, CAST, and rCAST scores were calculated based on the data collected. The predictive abilities of each score were tested using the area under the curve (AUC) of the receiver operating characteristic (ROC) curve. Results We identified 236 OHCA patients from computer-based medical records and analyzed 189 without missing data. In OHCA patients without bystander witnesses, CAHP and OHCA scores were not calculated. Although the predictive abilities of the scores were not significantly different, the NULL-PLEASE score had a large AUC of ROC curve in various OHCA patients. Furthermore, in patients with bystander-witnessed OHCA, the NULL-PLEASE score had large partial AUCs of ROC from sensitivity 0.8-1.0 and specificity 0.8-1.0. Conclusions The NULL-PLEASE score had a high, comprehensive predictive ability in various OHCA patients. Furthermore, the NULL-PLEASE score had a high predictive ability for good and poor neurological outcomes in patients with bystander-witnessed OHCA.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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