HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Health Sciences / Faculty of Health Sciences >
Peer-reviewed Journal Articles, etc >

Accumulation of Senescent Neural Cells in Murine Lupus With Depression-Like Behavior

Files in This Item:

The file(s) associated with this item can be obtained from the following URL:

Title: Accumulation of Senescent Neural Cells in Murine Lupus With Depression-Like Behavior
Authors: Saito, Yuki Browse this author →KAKEN DB
Miyajima, Maki Browse this author →KAKEN DB
Yamamoto, Sena Browse this author
Sato, Tsukasa Browse this author
Miura, Norihiro Browse this author
Fujimiya, Mineko Browse this author
Chikenji, Takako S. Browse this author →KAKEN DB
Keywords: systemic lupus erythematosus
SASP (senescence-associated secretory phenotype)
Issue Date: 3-Nov-2021
Publisher: Frontiers Media
Journal Title: Frontiers in immunology
Volume: 12
Start Page: 692321
Publisher DOI: 10.3389/fimmu.2021.692321
Abstract: Neuropsychiatric manifestations targeting the central, peripheral, and autonomic nervous system are common in systemic lupus erythematosus (SLE); collectively, these symptoms are termed neuropsychiatric SLE (NPSLE). Among a wide variety of neuropsychiatric symptoms, depression is observed in about 24-39% of SLE patients. Several cytokines and chemokines have been identified as biomarkers or therapeutic targets of NPSLE; in particular, the levels of type 1 interferons, TNFs, and IL-6 are elevated in SLE patient's cerebrospinal fluid (CSF), and these factors contribute to the pathology of depression. Here, we show that senescent neural cells accumulate in the hippocampal cornu ammonis 3 (CA3) region in MRL/lpr SLE model mice with depressive behavior. Furthermore, oral administration of fisetin, a senolytic drug, reduced the number of senescent neural cells and reduced depressive behavior in the MRL/lpr mice. In addition, transcription of several senescence and senescence-associated secretory phenotype (SASP) factors in the hippocampal region also decreased after fisetin treatment in the MRL/lpr mice. These results indicate that the accumulation of senescent neural cells in the hippocampus plays a role in NPSLE pathogenesis, and therapies targeting senescent cells may represent a candidate approach to treat NPSLE.
Type: article
Appears in Collections:保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Export metadata:

OAI-PMH ( junii2 , jpcoar_1.0 )

MathJax is now OFF:


 - Hokkaido University