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CD47 promotes T-cell lymphoma metastasis by up-regulating AKAP13-mediated RhoA activation

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Title: CD47 promotes T-cell lymphoma metastasis by up-regulating AKAP13-mediated RhoA activation
Authors: Kitai, Yuichi Browse this author →KAKEN DB
Ishiura, Marie Browse this author
Saitoh, Kodai Browse this author
Matsumoto, Naoki Browse this author
Owashi, Kimiya Browse this author
Yamada, Shunsuke Browse this author
Muromoto, Ryuta Browse this author →KAKEN DB
Kashiwakura, Jun-ichi Browse this author →KAKEN DB
Oritani, Kenji Browse this author →KAKEN DB
Matsuda, Tadashi Browse this author →KAKEN DB
Keywords: integrin
small-G protein
Issue Date: 6-Jan-2021
Publisher: Oxford University Press
Journal Title: International immunology
Volume: 33
Issue: 5
Start Page: 273
End Page: 280
Publisher DOI: 10.1093/intimm/dxab002
Abstract: CD47, a 50 kDa transmembrane protein, facilitates integrin-mediated cell adhesion and inhibits cell engulfment by phagocytes. Since CD47 blocking promotes engulfment of cancer cells by macrophages, it is important to clarify the mechanism of CD47 signaling in order to develop treatments for diseases involving CD47-overexpressing cancer cells, including breast cancer and lymphoma. Here, we show that CD47 plays an essential role in T-cell lymphoma metastasis by up-regulating basal RhoA activity independent of its anti-phagocytic function. CD47 interacts with AKAP13, a RhoA-specific guanine nucleotide exchange factor (GEF), and facilitates AKAP13-mediated RhoA activation. Our study shows that CD47 has a novel function on the AKAP13-RhoA axis and suggests that CD47-AKAP13 interaction would be a novel target for T-cell lymphoma treatment.
Rights: This is a pre-copyedited, author-produced version of an article accepted for publication in International immunology following peer review. The version of record International Immunology 2021 33(5):273–280 is available online at:
Type: article (author version)
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 鍛代悠一

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