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CD47 promotes T-cell lymphoma metastasis by up-regulating AKAP13-mediated RhoA activation
Title: | CD47 promotes T-cell lymphoma metastasis by up-regulating AKAP13-mediated RhoA activation |
Authors: | Kitai, Yuichi Browse this author →KAKEN DB | Ishiura, Marie Browse this author | Saitoh, Kodai Browse this author | Matsumoto, Naoki Browse this author | Owashi, Kimiya Browse this author | Yamada, Shunsuke Browse this author | Muromoto, Ryuta Browse this author →KAKEN DB | Kashiwakura, Jun-ichi Browse this author →KAKEN DB | Oritani, Kenji Browse this author →KAKEN DB | Matsuda, Tadashi Browse this author →KAKEN DB |
Keywords: | integrin | phagocytosis | Rho-GEF | small-G protein | TSP-1 |
Issue Date: | 6-Jan-2021 |
Publisher: | Oxford University Press |
Journal Title: | International immunology |
Volume: | 33 |
Issue: | 5 |
Start Page: | 273 |
End Page: | 280 |
Publisher DOI: | 10.1093/intimm/dxab002 |
Abstract: | CD47, a 50 kDa transmembrane protein, facilitates integrin-mediated cell adhesion and inhibits cell engulfment by phagocytes. Since CD47 blocking promotes engulfment of cancer cells by macrophages, it is important to clarify the mechanism of CD47 signaling in order to develop treatments for diseases involving CD47-overexpressing cancer cells, including breast cancer and lymphoma. Here, we show that CD47 plays an essential role in T-cell lymphoma metastasis by up-regulating basal RhoA activity independent of its anti-phagocytic function. CD47 interacts with AKAP13, a RhoA-specific guanine nucleotide exchange factor (GEF), and facilitates AKAP13-mediated RhoA activation. Our study shows that CD47 has a novel function on the AKAP13-RhoA axis and suggests that CD47-AKAP13 interaction would be a novel target for T-cell lymphoma treatment. |
Rights: | This is a pre-copyedited, author-produced version of an article accepted for publication in International immunology following peer review. The version of record International Immunology 2021 33(5):273–280 is available online at: https://doi.org/10.1093/intimm/dxab002. |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/83760 |
Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 鍛代悠一
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