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EEG Contribution to the Diagnosis of Antibody-Negative Autoimmune Encephalitis : A Case Report

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Title: EEG Contribution to the Diagnosis of Antibody-Negative Autoimmune Encephalitis : A Case Report
Authors: Mito, Mayusa Browse this author
Sakurai, Kotaro Browse this author
Nakamura, Yuichi Browse this author
Nagai, Azusa Browse this author
Seo, Sho Browse this author
Tanaka, Keiko Browse this author
Yabe, Ichiro Browse this author →KAKEN DB
Kusumi, Ichiro Browse this author →KAKEN DB
Keywords: Autoimmune diseases
Issue Date: Sep-2021
Publisher: Karger
Journal Title: Case reports in neurology
Volume: 13
Issue: 3
Start Page: 739
End Page: 743
Publisher DOI: 10.1159/000519991
Abstract: Autoimmune encephalitis (AE) is a group of inflammatory brain diseases that are characterized by prominent neuropsychiatric symptoms. Early therapeutic intervention is important for AE. Therefore, without waiting for autoantibody test results, clinicians must consider the possibility of AE based solely on clinical symptoms and conventional test results. The case described herein is of antibody-negative encephalitis with abnormalities shown only by EEG, which contributed to the diagnosis and treatment. The patient, a 20-year-old woman, showed autonomic seizures in addition to movement disorders, psychiatric symptoms, and cognitive dysfunction, which worsened subacutely. Her seizures and movement disorders were not responsive to antiepileptic medications. Results obtained from MRI and cerebrospinal fluid (CSF) were normal; EEG findings showed repeated spikes in the right temporal area, with changes over time. Based on the clinical course and EEG, along with administered immunotherapy, which resolved seizures, movement disorders, and psychiatric symptoms, we suspected AE. For diagnosis of AE and for evaluating treatment responsiveness, EEG was useful. Results indicate that EEG can assist clinicians even with AE cases for which MRI and CSF findings are normal. (C) 2021 The Author(s). Published by S. Karger AG, Basel.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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