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Flazin as a Lipid Droplet Regulator against Lipid Disorders

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Title: Flazin as a Lipid Droplet Regulator against Lipid Disorders
Authors: Wu, Xunzhi Browse this author
Chen, Zhen Browse this author →KAKEN DB
Wu, Yue Browse this author
Chen, Yifan Browse this author
Jia, Jiaping Browse this author
Shen, Nianqiu Browse this author
Chiba, Hitoshi Browse this author →KAKEN DB
Hui, Shu-Ping Browse this author →KAKEN DB
Keywords: lipid-storage disorders
metabolic diseases
diabetic nephropathy
functional foods
lipid metabolism
mass spectrometry
Issue Date: 3-Apr-2022
Publisher: MDPI
Journal Title: Nutrients
Volume: 14
Issue: 7
Start Page: 1501
Publisher DOI: 10.3390/nu14071501
PMID: 35406114
Abstract: Lipid disorders are closely related to numerous metabolic diseases, and lipid droplets (LDs) have been considered as a new target for regulating lipid metabolism. Dietary intervention and nutraceuticals provide safe and long-term beneficial effects for treating metabolic diseases. Flazin is a diet-derived bioactive constituent mainly existing in fermented foods, of which the lipid metabolism improvement function has not been studied. In this study, the effect of flazin on lipid regulation at both cell level and organelle level was investigated. Lipidomic profiling showed that flazin significantly decreased cellular triglyceride (TG) by 12.0-22.4% compared with modeling groups and improved the TG and free fatty acid profile. LD staining revealed that flazin efficiently reduced both cellular neutral lipid content by 17.4-53.9% and LD size by 10.0-35.3%. Furthermore, nanoelectrospray ionization mass spectrometry analysis proved that flazin exhibited a preferential suppression of LD TG and regulated LD morphology, including a size decrease and surface property improvement. An evaluation of related gene expression suggested the mechanism to be lipolysis promotion and lipogenesis inhibition. These findings indicated that flazin might be an LD regulator for reversing lipid metabolism disturbance. Moreover, the strategy proposed in this study may contribute to developing other nutraceuticals for treating lipid disorder-related metabolic diseases.
Type: article
Appears in Collections:保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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