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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine >
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Updating the influenza virus library at Hokkaido University : It's potential for the use of pandemic vaccine strain candidates and diagnosis
| Title: | Updating the influenza virus library at Hokkaido University : It's potential for the use of pandemic vaccine strain candidates and diagnosis |
| Authors: | Nomura, Naoki Browse this author | | Matsuno, Keita Browse this author →KAKEN DB | | Shingai, Masashi Browse this author →KAKEN DB | | Ohno, Marumi Browse this author →KAKEN DB | | Sekiya, Toshiki Browse this author | | Omori, Ryosuke Browse this author →KAKEN DB | | Sakoda, Yoshihiro Browse this author →KAKEN DB | | Webster, Robert G. Browse this author | | Kida, Hiroshi Browse this author →KAKEN DB |
| Keywords: | Pandemic influenza vaccine | | Influenza virus library | | Hemagglutinin |
| Issue Date: | 1-May-2021 |
| Publisher: | Elsevier |
| Journal Title: | Virology |
| Volume: | 557 |
| Start Page: | 55 |
| End Page: | 61 |
| Publisher DOI: | 10.1016/j.virol.2021.02.005 |
| Abstract: | Genetic reassortment of influenza A viruses through cross-species transmission contributes to the generation of pandemic influenza viruses. To provide information on the ecology of influenza viruses, we have been conducting a global surveillance of zoonotic influenza and establishing an influenza virus library. Of 4580 influenza virus strains in the library, 3891 have been isolated from over 70 different bird species. The remaining 689 strains were isolated from humans, pigs, horses, seal, whale, and the environment. Phylogenetic analyses of the HA genes of the library isolates demonstrate that the library strains are distributed to all major known clusters of the H1, H2 and H3 subtypes of HA genes that are prevalent in humans. Since past pandemic influenza viruses are most likely genetic reassortants of zoonotic and seasonal influenza viruses, a vast collection of influenza A virus strains from various hosts should be useful for vaccine preparation and diagnosis for future pandemics. |
| Rights: | Under an Elsevier user license [https://www.elsevier.com/open-access/userlicense/1.0/] |
| Type: | article |
| URI: | http://hdl.handle.net/2115/85184 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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