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Editorial: Non-Coding RNAs in Gastrointestinal and Gynecological Cancers: New Insights Into the Mechanisms of Cancer Therapeutic Resistance
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| Title: | Editorial: Non-Coding RNAs in Gastrointestinal and Gynecological Cancers: New Insights Into the Mechanisms of Cancer Therapeutic Resistance |
| Authors: | Dong, Peixin Browse this author →KAKEN DB | | Wang, Feng Browse this author | | Chang, Lei Browse this author | | Yue, Junming Browse this author |
| Keywords: | non-coding RNA | | microRNA | | long non-coding RNA | | circular RNA | | chemoresistance | | cancer stem cells | | gastrointestinal cancer | | gynecological cancer |
| Issue Date: | 13-May-2022 |
| Journal Title: | Frontiers in Cell and Developmental Biology |
| Volume: | 10 |
| Start Page: | 893868 |
| Publisher DOI: | 10.3389/fcell.2022.893868 |
| Abstract: | Background Chemoresistance is mediated by a variety of molecular mechanisms, including inhibition of drug influx, increased drug efflux, evasion of cell apoptosis, enhanced repair of DNA damage, induction of epithelial-mesenchymal transition (EMT), activation of cancer stem-like features, induction of autophagy, alterations in cancer metabolism, mutations of drug targets, and dynamic interactions between tumor cells and their surrounding microenvironment (Holohan et al., 2013). Tumor cells can become resistant to chemotherapeutic agents through a combination of different mechanisms (Vasan et al., 2019). Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), have been implicated in chemoresistance (Wang et al., 2019).
In this research topic, 21 papers (including thirteen reviews and eight original research articles) that have shed light on the therapeutic resistance mechanisms controlled by non-coding RNAs in human gastrointestinal and gynecological cancers were chosen. The latest findings presented in this Research Topic add to our understanding of the mechanisms by which non-coding RNAs govern cancer cell resistance to chemotherapy, and may also point to meaningful molecular targets that could be utilized to eliminate chemoresistance and increase the survival of cancer patients. |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/85456 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 董 培新
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