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Editorial : Non-Coding RNAs in Gastrointestinal and Gynecological Cancers : New Insights Into the Mechanisms of Cancer Therapeutic Resistance

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/85456

Title: Editorial : Non-Coding RNAs in Gastrointestinal and Gynecological Cancers : New Insights Into the Mechanisms of Cancer Therapeutic Resistance
Authors: Dong, Peixin Browse this author →KAKEN DB
Wang, Feng Browse this author
Chang, Lei Browse this author
Yue, Junming Browse this author
Keywords: non-coding RNA
microRNA
long non-coding RNA
circular RNA
chemoresistance
cancer stem cells
gastrointestinal cancer
gynecological cancer
Issue Date: 13-May-2022
Journal Title: Frontiers in Cell and Developmental Biology
Volume: 10
Start Page: 893868
Publisher DOI: 10.3389/fcell.2022.893868
Abstract: Chemoresistance is mediated by a variety of molecular mechanisms, including inhibition of drug influx,increased drug efflux, evasion of cell apoptosis, enhanced repair of DNA damage, induction of epithelial-mesenchymal transition (EMT), activation of cancer stem-like features, induction of autophagy,alterations in cancer metabolism, mutations of drug targets, and dynamic interactions betweentumor cells and their surrounding microenvironment (Holohan et al., 2013). Tumor cells canbecome resistant to chemotherapeutic agents through a combination of different mechanisms (Vasanet al., 2019). Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long non-coding RNAs(lncRNAs), and circular RNAs (circRNAs),have been implicated in chemoresistance (Wang et al., 2019).In this research topic, 21 papers (including thirteen reviews and eight original research articles)that have shed light on the therapeutic resistance mechanisms controlled by non-coding RNAs inhuman gastrointestinal and gynecological cancers were chosen. The latestfindings presented in thisResearch Topic add to our understanding of the mechanisms by which non-coding RNAs governcancer cell resistance to chemotherapy, and may also point to meaningful molecular targets thatcould be utilized to eliminate chemoresistance and increase the survival of cancer patients.
Rights: https://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/85456
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 董 培新

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