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Soluble Interleukin-2 Receptor Predicts Treatment Outcome in Patients With Autoimmune Tubulointerstitial Nephritis. A Preliminary Study

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Title: Soluble Interleukin-2 Receptor Predicts Treatment Outcome in Patients With Autoimmune Tubulointerstitial Nephritis. A Preliminary Study
Authors: Shiratori-Aso, Satoka Browse this author
Nakazawa, Daigo Browse this author →KAKEN DB
Nishio, Saori Browse this author →KAKEN DB
Ueda, Yusho Browse this author
Eguchi, Mina Browse this author
Yokoyama, Ai Browse this author
Yoshikawa, Junpei Browse this author
Kudo, Takashi Browse this author
Watanabe-Kusunoki, Kanako Browse this author
Takeda-Otera, Sayo Browse this author
Yamamoto, Junya Browse this author
Matsuoka, Naoko Browse this author
Kaneshima, Nobuharu Browse this author
Hattanda, Fumihiko Browse this author
Iwasaki, Sari Browse this author →KAKEN DB
Tsuji, Takahiro Browse this author →KAKEN DB
Fukasawa, Yuichiro Browse this author
Atsumi, Tatsuya Browse this author →KAKEN DB
Keywords: tubulointerstitial nephritis
soluble interleukin-2 receptor
autoimmune disease
therapeutic response
Issue Date: 25-Feb-2022
Publisher: Frontiers Media
Journal Title: Frontiers in medicine
Volume: 9
Start Page: 827388
Publisher DOI: 10.3389/fmed.2022.827388
Abstract: BackgroundAutoimmune tubulointerstitial nephritis (TIN) is characterized by immune-mediated tubular injury and requires immunosuppressive therapy. However, diagnosing TIN and assessing therapeutic response are challenging for clinicians due to the lack of useful biomarkers. Pathologically, CD4(+) T cells infiltrate to renal tubulointerstitium, and soluble interleukin-2 receptor (sIL-2R) has been widely known as a serological marker of activated T cell. Here, we explored the usefulness of serum sIL-2R to predict the treatment outcome in patients with autoimmune TIN. MethodsStudy Design: Single-center retrospective observational study. Participants62 patients were diagnosed of TIN from 2005 to April 2018 at Hokkaido University Hospital. Among them, 30 patients were diagnosed with autoimmune TIN and treated with corticosteroids. We analyzed the association between baseline characteristics including sIL-2R and the change of estimated glomerular filtration rate (eGFR) after initiation of corticosteroids. ResultsThe serum sIL-2R level in patients with autoimmune TIN was significantly higher than that in chronic kidney disease patients with other causes. Mean eGFR in autoimmune TIN patients treated with corticosteroids increased from 43.3 +/- 20.4 mL/min/1.73 m(2) (baseline) to 50.7 +/- 19.9 mL/min/1.73 m(2) (3 months) (Delta eGFR; 22.8 +/- 26.0%). Multivariate analysis revealed that higher sIL-2R (per 100 U/mL, beta = 1.102, P < 0.001) level was independently associated with the renal recovery. In ROC analysis, sIL-2R had the best area under the curve value (0.805) and the cutoff point was 1182 U/mL (sensitivity = 0.90, 1-specificity = 0.45). ConclusionsOur study showed that elevated serum sIL-2R levels might become a potential predictive marker for therapeutic response in autoimmune TIN.
Type: article
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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