| Title: | Soluble Interleukin-2 Receptor Predicts Treatment Outcome in Patients With Autoimmune Tubulointerstitial Nephritis. A Preliminary Study |
| Authors: | Shiratori-Aso, Satoka Browse this author |
| Nakazawa, Daigo Browse this author →KAKEN DB |
| Nishio, Saori Browse this author →KAKEN DB |
| Ueda, Yusho Browse this author |
| Eguchi, Mina Browse this author |
| Yokoyama, Ai Browse this author |
| Yoshikawa, Junpei Browse this author |
| Kudo, Takashi Browse this author |
| Watanabe-Kusunoki, Kanako Browse this author |
| Takeda-Otera, Sayo Browse this author |
| Yamamoto, Junya Browse this author |
| Matsuoka, Naoko Browse this author |
| Kaneshima, Nobuharu Browse this author |
| Hattanda, Fumihiko Browse this author |
| Iwasaki, Sari Browse this author →KAKEN DB |
| Tsuji, Takahiro Browse this author →KAKEN DB |
| Fukasawa, Yuichiro Browse this author |
| Atsumi, Tatsuya Browse this author →KAKEN DB |
| Keywords: | tubulointerstitial nephritis |
| soluble interleukin-2 receptor |
| autoimmune disease |
| therapeutic response |
| biomarkers |
| Issue Date: | 25-Feb-2022 |
| Publisher: | Frontiers Media |
| Journal Title: | Frontiers in medicine |
| Volume: | 9 |
| Start Page: | 827388 |
| Publisher DOI: | 10.3389/fmed.2022.827388 |
| Abstract: | BackgroundAutoimmune tubulointerstitial nephritis (TIN) is characterized by immune-mediated tubular injury and requires immunosuppressive therapy. However, diagnosing TIN and assessing therapeutic response are challenging for clinicians due to the lack of useful biomarkers. Pathologically, CD4(+) T cells infiltrate to renal tubulointerstitium, and soluble interleukin-2 receptor (sIL-2R) has been widely known as a serological marker of activated T cell. Here, we explored the usefulness of serum sIL-2R to predict the treatment outcome in patients with autoimmune TIN. MethodsStudy Design: Single-center retrospective observational study. Participants62 patients were diagnosed of TIN from 2005 to April 2018 at Hokkaido University Hospital. Among them, 30 patients were diagnosed with autoimmune TIN and treated with corticosteroids. We analyzed the association between baseline characteristics including sIL-2R and the change of estimated glomerular filtration rate (eGFR) after initiation of corticosteroids. ResultsThe serum sIL-2R level in patients with autoimmune TIN was significantly higher than that in chronic kidney disease patients with other causes. Mean eGFR in autoimmune TIN patients treated with corticosteroids increased from 43.3 +/- 20.4 mL/min/1.73 m(2) (baseline) to 50.7 +/- 19.9 mL/min/1.73 m(2) (3 months) (Delta eGFR; 22.8 +/- 26.0%). Multivariate analysis revealed that higher sIL-2R (per 100 U/mL, beta = 1.102, P < 0.001) level was independently associated with the renal recovery. In ROC analysis, sIL-2R had the best area under the curve value (0.805) and the cutoff point was 1182 U/mL (sensitivity = 0.90, 1-specificity = 0.45). ConclusionsOur study showed that elevated serum sIL-2R levels might become a potential predictive marker for therapeutic response in autoimmune TIN. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/85508 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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