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Intrathecal Injection of Mesenchymal Stromal Cell Cultured on 3D Fiber Ameliorates Multiple Organ Damage in Murine Lupus

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Title: Intrathecal Injection of Mesenchymal Stromal Cell Cultured on 3D Fiber Ameliorates Multiple Organ Damage in Murine Lupus
Authors: Saito, Yuki Browse this author →KAKEN DB
Miyajima, Maki Browse this author →KAKEN DB
Yamamoto, Sena Browse this author
Miura, Norihiro Browse this author
Sato, Tsukasa Browse this author
Kita, Arisa Browse this author →KAKEN DB
Ijima, Shogo Browse this author
Fujimiya, Mineko Browse this author →KAKEN DB
Chikenji, Takako S. Browse this author →KAKEN DB
Keywords: systemic lupus erythematosus
bone marrow
mesenchymal stromal cell
multiple organ damage
sympathetic nervous system
Issue Date: 25-Apr-2022
Publisher: Oxford University Press
Journal Title: Stem cells translational medicine
Volume: 11
Issue: 6
Start Page: 644
End Page: 658
Publisher DOI: 10.1093/stcltm/szac021
PMID: 35466994
Abstract: Up to 60% of patients with systemic lupus erythematosus (SLE) experience autonomic symptom. Sympathetic nervous system damage can cause dysfunction of the bone marrow that activates inflammatory cells, potentially causing multiple organ damage. We hypothesized that sympathetic nervous system damage would induce bone marrow dysfunction with multiple organ damage in SLE, and that multiple organ damage could be improved by therapy targeting the nervous system. Here, we showed that damage to autonomic nerves and Schwann cells occurred in the bone marrow and central nervous system of SLE model mice. A neurotoxic drug increased mortality and induced severe neuropathy and multiple organ damage, while a neuroprotective drug prevented multiple organ damage. The administration of bone marrow-derived mesenchymal stromal cells (BMSCs) cultured on a 3-dimensional fiber scaffold improved bone marrow neuropathy, skin lesions, kidney function, and mortality. Our results reveal that bone marrow neuropathy influence multiple organ damage associated with SLE, and improvement of bone marrow neuropathy by intrathecal injection of BMSC may be a target for SLE multiple-organ damage.
Type: article
Appears in Collections:保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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