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Plasma Angiopoietin-Like Protein 2 Levels and Mortality Risk Among Younger-Old Japanese People : A Population-Based Case-Cohort Study

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Title: Plasma Angiopoietin-Like Protein 2 Levels and Mortality Risk Among Younger-Old Japanese People : A Population-Based Case-Cohort Study
Authors: Zhao, Wenjing Browse this author
Morinaga, Jun Browse this author
Ukawa, Shigekazu Browse this author
Endo, Motoyoshi Browse this author
Yamada, Hiroya Browse this author
Kawamura, Takashi Browse this author
Wakai, Kenji Browse this author
Tsushita, Kazuyo Browse this author
Ando, Masahiko Browse this author
Suzuki, Koji Browse this author
Oike, Yuichi Browse this author
Tamakoshi, Akiko Browse this author →KAKEN DB
Keywords: Biomarkers
Issue Date: Jun-2022
Publisher: Oxford University Press
Journal Title: Journals of Gerontology: Series A
Volume: 77
Issue: 6
Start Page: 1150
End Page: 1158
Publisher DOI: 10.1093/gerona/glac017
Abstract: Aging is an important medical and social problem. Excessive angiopoietin-like protein (ANGPTL)-2 signaling causes chronic tissue inflammation, promoting development and progression of aging-related diseases. Moreover, circulating ANGPTL2 levels reportedly predict the risk of some aging-related diseases and subsequent death. However, there are, as yet, no reports of whether circulating ANGPTL2 levels predict vital prognosis in younger-old, community-dwelling populations. This study investigated associations between plasma ANGPTL2 levels and all-cause and specific-cause mortality in this population. The case-cohort study was abstracted from an ongoing, age-specific prospective cohort study: the New Integrated Suburban Seniority Investigation Project. This project enrolled 3 073 participants aged 64 years at the beginning of the investigation from 1996 through 2005. A subcohort of 714 randomly sampled participants plus 387 cases representing deceased participants followed through 2015 underwent survival analysis. Plasma ANGPTL2 concentrations were positively associated with >80% and 100% higher risk of all-cause mortality and cancer mortality, respectively, after adjustment for gender, smoking, alcohol consumption, walking time, sleep duration, caloric intake, medical status, disease history, BMI, and triglyceride, creatinine, uric acid, and high sensitivity C-reactive protein levels. A more robust association between ANGPTL2 levels and all-cause and cancer mortality was seen in participants with either frailties or with lifestyles of heavier drinking or current smoking. Elevated plasma ANGPTL2 levels are associated with high all-cause and cancer mortality in a community-dwelling sample of younger-old adults. These findings expand our knowledge of human aging and associated diseases.
Rights: This article has been accepted for publication in The Journals of Gerontology: Series A ©: 2022 The Author(s) Published by Oxford University Press on behalf of The Royal Astronomical Society. All rights reserved.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 玉腰 暁子

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