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Collagen XVII deficiency alters epidermal patterning

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Title: Collagen XVII deficiency alters epidermal patterning
Authors: Wang, Yunan Browse this author
Kitahata, Hiroyuki Browse this author
Kosumi, Hideyuki Browse this author
Watanabe, Mika Browse this author
Fujimura, Yu Browse this author
Takashima, Shota Browse this author
Osada, Shin-Ichi Browse this author
Hirose, Tomonori Browse this author
Nishie, Wataru Browse this author
Nagayama, Masaharu Browse this author
Shimizu, Hiroshi Browse this author
Natsuga, Ken Browse this author →KAKEN DB
Issue Date: 1-Jun-2022
Publisher: Springer Nature
Journal Title: Laboratory investigation
Volume: 102
Issue: 6
Start Page: 581
End Page: 588
Publisher DOI: 10.1038/s41374-022-00738-2
Abstract: Vertebrates exhibit patterned epidermis, exemplified by scales/interscales in mice tails and grooves/ridges on the human skin surface (microtopography). Although the role of spatiotemporal regulation of stem cells (SCs) has been implicated in this process, the mechanism underlying the development of such epidermal patterns is poorly understood. Here, we show that collagen XVII (COL17), a niche for epidermal SCs, helps stabilize epidermal patterns. Gene knockout and rescue experiments revealed that COL17 maintains the width of the murine tail scale epidermis independently of epidermal cell polarity. Skin regeneration after wounding was associated with slender scale epidermis, which was alleviated by overexpression of human COL17. COL17-negative skin in human junctional epidermolysis bullosa showed a distinct epidermal pattern from COL17-positive skin that resulted from revertant mosaicism. These results demonstrate that COL17 contributes to defining mouse tail scale shapes and human skin microtopography. Our study sheds light on the role of the SC niche in tissue pattern formation. Mammals exhibit epidermal patterning, as seen in mouse tail scales and human skin microtopography. In this article, the authors demonstrate that type XVII collagen (COL17), a niche for epidermal stem cells, modulate epidermal patterning in mice and humans. COL17 further prevents wound-induced epidermal deformation. This study paves the way for elucidating the role of the stem cell niche in tissue pattern formation.
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 夏賀 健

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