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Possible role of epiregulin from dermal fibroblasts in the keratinocyte hyperproliferation of psoriasis

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Title: Possible role of epiregulin from dermal fibroblasts in the keratinocyte hyperproliferation of psoriasis
Authors: Iwata, Hiroaki Browse this author →KAKEN DB
Haga, Naoya Browse this author
Ujiie, Hideyuki Browse this author →KAKEN DB
Keywords: acanthosis
growth factor
Issue Date: Sep-2021
Publisher: John Wiley & Sons
Journal Title: Journal of dermatology
Volume: 48
Issue: 9
Start Page: 1433
End Page: 1438
Publisher DOI: 10.1111/1346-8138.16003
Abstract: Psoriasis, an immune-mediated inflammatory disease, is characterized by keratinocyte hyperproliferation. Tumor necrosis factor (TNF)-alpha, interleukin (IL)-23, and IL-17A play critical roles in the pathogenesis of psoriasis. IL-17A secreted by T-helper 17 acts more directly against keratinocytes than TNF-alpha or IL-23 do. Regarding the receptors of cytokines, fibroblasts also express receptors against IL-17A and TNF-alpha, and induce the production of growth factors. Epiregulin (EREG), an epidermal growth factor receptor ligand, is produced by both keratinocytes and fibroblasts. EREG enhances keratinocyte proliferation and differentiation. We hypothesized that fibroblasts stimulated with IL-17A and/or TNF-alpha may play a role in epidermal hyperproliferation through the production of epidermal growth factors in psoriasis. The mRNA expression of EREG was found to be significantly upregulated by co-stimulation with IL-17A and TNF-alpha (mean, 49.2-fold). Furthermore, the stimulation with TNF-alpha alone, but not IL-17A alone, induced significant increases. Immunofluorescent staining demonstrated that the protein expression level of EREG was also increased in fibroblasts stimulated with these cytokines. Stimulation with EREG significantly enhanced keratinocyte proliferation in vitro. In human psoriatic patients' skin, immunofluorescence staining of EREG showed significantly high intensity in the dermis of lesional skin. In conclusion, cytokine stimulation with TNF-alpha and IL-17A induces the overexpression of EREG from dermal fibroblasts in the lesional skin of psoriasis, and plays a role in epidermal hyperproliferation.
Rights: This is the peer reviewed version of the following article: Iwata, H, Haga, N, Ujiie, H. Possible role of epiregulin from dermal fibroblasts in the keratinocyte hyperproliferation of psoriasis. J Dermatol. 2021; 48: 1433–1438, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 岩田 浩明

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