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Temporal trends of perfluoroalkyl acids in plasma samples of pregnant women in Hokkaido, Japan, 2003–2011
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| Title: | Temporal trends of perfluoroalkyl acids in plasma samples of pregnant women in Hokkaido, Japan, 2003–2011 |
| Authors: | Okada, Emiko Browse this author | | Kashino, Ikuko Browse this author | | Matsuura, Hideyuki Browse this author | | Sasaki, Seiko Browse this author →KAKEN DB | | Miyashita, Chihiro Browse this author →KAKEN DB | | Yamamoto, Jun Browse this author | | Ikeno, Tamiko Browse this author →KAKEN DB | | Ito, Yoichi M. Browse this author →KAKEN DB | | Matsumura, Toru Browse this author | | Tamakoshi, Akiko Browse this author →KAKEN DB | | Kishi, Reiko Browse this author →KAKEN DB |
| Keywords: | Perfluorooctane sulfonate | | Perfluorooctanoic acid | | Perfluorononanoic acid | | Perfluorodecanoic aci | | Human maternal plasma | | Temporal trend |
| Issue Date: | 1-Oct-2013 |
| Publisher: | Elsevier |
| Journal Title: | Environment International |
| Volume: | 60 |
| Start Page: | 89 |
| End Page: | 96 |
| Publisher DOI: | 10.1016/j.envint.2013.07.013 |
| Abstract: | Perfluoroalkyl acids (PFAAs) are persistent organic pollutants that are used in a wide range of consumer products. Recent epidemiological studies have shown that prenatal exposure to toxic levels of PFAAs in the environment may adversely affect fetal growth and humoral immune response in infants and children. Here we have characterized levels of prenatal exposure to PFAA between 2003 and 2011 in Hokkaido, Japan, by measuring PFAA concentrations in plasma samples from pregnant women. The study population comprised 150 women who enrolled in a prospective birth cohort study conducted in Hokkaido. Eleven PFAAs were measured in maternal plasma samples using simultaneous analysis by ultra-performance liquid chromatography coupled to triple quadrupole tandem mass spectrometry. At the end of the study, in 2011, age- and parity-adjusted mean concentrations of perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluoroundecanoic acid (PFUnDA), perfluorododecanoic acid (PFDoDA), perfluorotridecanoic acid (PFTrDA), perfluorohexane sulfonate (PFHxS), and perfluorooctane sulfonate (PFOS) were 1.35ng/mL, 1.26ng/mL, 0.66ng/mL, 1.29ng/mL, 0.25ng/mL, 0.33ng/mL, 0.28ng/mL, and 3.86ng/mL, respectively. Whereas PFOS and PFOA concentrations declined 8.4%/y and 3.1%/y, respectively, PFNA and PFDA levels increased 4.7%/y and 2.4%/y, respectively, between 2003 and 2011. PFUnDA, PFDoDA, and PFTrDA were detected in the vast majority of maternal samples, but no significant temporal trend was apparent. Future studies must involve a larger population of pregnant women and their children to determine the effects of prenatal exposure to PFAA on health outcomes in infants and children. |
| Rights: | © 2013. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/87332 |
| Appears in Collections: | 環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 岸 玲子
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