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Temporal trends of perfluoroalkyl acids in plasma samples of pregnant women in Hokkaido, Japan, 2003–2011

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Title: Temporal trends of perfluoroalkyl acids in plasma samples of pregnant women in Hokkaido, Japan, 2003–2011
Authors: Okada, Emiko Browse this author
Kashino, Ikuko Browse this author
Matsuura, Hideyuki Browse this author
Sasaki, Seiko Browse this author →KAKEN DB
Miyashita, Chihiro Browse this author →KAKEN DB
Yamamoto, Jun Browse this author
Ikeno, Tamiko Browse this author →KAKEN DB
Ito, Yoichi M. Browse this author →KAKEN DB
Matsumura, Toru Browse this author
Tamakoshi, Akiko Browse this author →KAKEN DB
Kishi, Reiko Browse this author →KAKEN DB
Keywords: Perfluorooctane sulfonate
Perfluorooctanoic acid
Perfluorononanoic acid
Perfluorodecanoic aci
Human maternal plasma
Temporal trend
Issue Date: 1-Oct-2013
Publisher: Elsevier
Journal Title: Environment International
Volume: 60
Start Page: 89
End Page: 96
Publisher DOI: 10.1016/j.envint.2013.07.013
Abstract: Perfluoroalkyl acids (PFAAs) are persistent organic pollutants that are used in a wide range of consumer products. Recent epidemiological studies have shown that prenatal exposure to toxic levels of PFAAs in the environment may adversely affect fetal growth and humoral immune response in infants and children. Here we have characterized levels of prenatal exposure to PFAA between 2003 and 2011 in Hokkaido, Japan, by measuring PFAA concentrations in plasma samples from pregnant women. The study population comprised 150 women who enrolled in a prospective birth cohort study conducted in Hokkaido. Eleven PFAAs were measured in maternal plasma samples using simultaneous analysis by ultra-performance liquid chromatography coupled to triple quadrupole tandem mass spectrometry. At the end of the study, in 2011, age- and parity-adjusted mean concentrations of perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluoroundecanoic acid (PFUnDA), perfluorododecanoic acid (PFDoDA), perfluorotridecanoic acid (PFTrDA), perfluorohexane sulfonate (PFHxS), and perfluorooctane sulfonate (PFOS) were 1.35ng/mL, 1.26ng/mL, 0.66ng/mL, 1.29ng/mL, 0.25ng/mL, 0.33ng/mL, 0.28ng/mL, and 3.86ng/mL, respectively. Whereas PFOS and PFOA concentrations declined 8.4%/y and 3.1%/y, respectively, PFNA and PFDA levels increased 4.7%/y and 2.4%/y, respectively, between 2003 and 2011. PFUnDA, PFDoDA, and PFTrDA were detected in the vast majority of maternal samples, but no significant temporal trend was apparent. Future studies must involve a larger population of pregnant women and their children to determine the effects of prenatal exposure to PFAA on health outcomes in infants and children.
Rights: © 2013. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 岸 玲子

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