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STAP-2 Adaptor Protein Regulates Multiple Steps of Immune and Inflammatory Responses
| Title: | STAP-2 Adaptor Protein Regulates Multiple Steps of Immune and Inflammatory Responses |
| Authors: | Matsuda, Tadashi Browse this author →KAKEN DB | | Oritani, Kenji Browse this author →KAKEN DB |
| Keywords: | signal-transducing adaptor protein (STAP)-2 | | adaptor protein | | immune response | | inflammation | | signal transduction |
| Issue Date: | 1-Jul-2021 |
| Publisher: | The Pharmaceutical Society of Japan |
| Journal Title: | Biological and Pharmaceutical Bulletin |
| Volume: | 44 |
| Issue: | 7 |
| Start Page: | 895 |
| End Page: | 901 |
| Publisher DOI: | 10.1248/bpb.b21-00224 |
| PMID: | 34193686 |
| Abstract: | Signal-transducing adaptor protein (STAP)-2 is an adaptor molecule involved in regulation of several intracellular signaling events in immune cells. STAP-2 contains a pleckstrin homology domain at the N-terminus, an src homology domain in the central portion and a proline-rich region at the C-terminus. STAP-2 also has a YXXQ motif, which is a potential signal transducer and activator of transcription (STAT)3-binding site. STAP-2 influences the STAT3 and STAT5 activity, integrin-mediated T cell adhesion, chemokine-induced T cell migration, Fas-mediated T cell apoptosis, Toll-like receptor-mediated macrophage functions, macrophage colony-stimulating factor-induced macrophage activation, and the high-affinity immunoglobulin E receptor-mediated mast cell activation. This article reviews the current understanding of roles of the STAP-2 during immune and/or inflammatory responses, and discusses possible therapeutic applications of targeting STAP-2 proteins in immune-related disorders. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/87607 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 松田 正
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