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Possible Therapeutic Applications of Targeting STAP Proteins in Cancer

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Title: Possible Therapeutic Applications of Targeting STAP Proteins in Cancer
Authors: Matsuda, Tadashi Browse this author →KAKEN DB
Oritani, Kenji Browse this author →KAKEN DB
Keywords: signal-transducing adaptor protein (STAP)
adaptor protein
signal transduction
cancer cell growth
Issue Date: 1-Dec-2021
Publisher: The Pharmaceutical Society of Japan
Journal Title: Biological & pharmaceutical bulletin
Volume: 44
Issue: 12
Start Page: 1810
End Page: 1818
Publisher DOI: 10.1248/bpb.b21-00672
PMID: 34853263
Abstract: The signal-transducing adaptor protein (STAP) family, including STAP-1 and STAP-2, contributes to a variety of intracellular signaling pathways. The proteins in this family contain typical structures for adaptor proteins, such as Pleckstrin homology in the N-terminal regions and SRC homology 2 domains in the central regions. STAP proteins bind to inhibitor of kappaB kinase complex, breast tumor kinase, signal transducer and activator of transcription 3 (STAT3), and STAT5, during tumorigenesis and inflammatory/immune responses. STAP proteins positively or negatively regulate critical steps in intracellular signaling pathways through individually unique mechanisms. This article reviews the roles of the novel STAP family and the possible therapeutic applications of targeting STAP proteins in cancer.
Type: article
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 松田 正

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