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Cotton rats (Sigmodon hispidus) with a high prevalence of hydrocephalus without clinical symptoms

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Title: Cotton rats (Sigmodon hispidus) with a high prevalence of hydrocephalus without clinical symptoms
Authors: Kondoh, Daisuke Browse this author →KAKEN DB
Nakamura, Teppei Browse this author →KAKEN DB
Tsuji, Erika Browse this author
Hosotani, Marina Browse this author →KAKEN DB
Ichii, Osamu Browse this author →KAKEN DB
Irie, Takao Browse this author →KAKEN DB
Mishima, Takashi Browse this author
Nagasaki, Ken-ichi Browse this author
Kon, Yasuhiro Browse this author →KAKEN DB
Keywords: brain ventricle
ependymal cells
pyramidal cells
Issue Date: Feb-2022
Publisher: John Wiley & Sons
Journal Title: Neuropathology
Volume: 42
Issue: 1
Start Page: 16
End Page: 27
Publisher DOI: 10.1111/neup.12776
Abstract: Normal-pressure hydrocephalus (NPH) is a condition in which the ventricle is enlarged without elevated cerebrospinal fluid pressure, and it generally develops in later life and progresses slowly. A complete animal model that mimics human idiopathic NPH has not yet been established, and the onset mechanisms and detailed pathomechanisms of NPH are not fully understood. Here, we demonstrate a high spontaneous prevalence (34.6%) of hydrocephalus without clinical symptoms in inbred cotton rats (Sigmodon hispidus). In all 46 hydrocephalic cotton rats, the severity was mild or moderate and not severe. The dilation was limited to the lateral ventricles, and none of the hemorrhage, ventriculitis, meningitis, or tumor formation was found in hydrocephalic cotton rats. These findings indicate that the type of hydrocephalus in cotton rats is similar to that of communicating idiopathic NPH. Histopathological examinations revealed that the inner granular and pyramidal layers (layers IV and V) of the neocortex became thinner in hydrocephalic brains. A small number of pyramidal cells were positive for Fluoro-Jade C (a degenerating neuron marker) and ionized calcium-binding adaptor molecule 1 (Iba1)-immunoreactive microglia were in contact with the degenerating neurons in the hydrocephalic neocortex, suggesting that hydrocephalic cotton rats are more or less impaired projections from the neocortex. This study highlights cotton rats as a candidate for novel models to elucidate the pathomechanism of idiopathic NPH. Additionally, cotton rats have some noticeable systemic pathological phenotypes, such as chronic kidney disease and metabolic disorders. Thus, this model might also be useful for researching the comorbidities of NPH to other diseases.
Rights: This is the peer reviewed version of the following article: [Kondoh, D., Nakamura, T., Tsuji, E., Hosotani, M., Ichii, O., Irie, T., Mishima, T., Nagasaki, K.-i. and Kon, Y. (2022), Cotton rats (Sigmodon hispidus) with a high prevalence of hydrocephalus without clinical symptoms. Neuropathology, 42: 16-27.], which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Type: article (author version)
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 中村 鉄平

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