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Beneficial effects of a new neuroprotective compound in neuronal cells and MPTP-administered mouse model of Parkinson's disease
| Title: | Beneficial effects of a new neuroprotective compound in neuronal cells and MPTP-administered mouse model of Parkinson's disease |
| Authors: | Kato, Izumi Browse this author | | Ogawa, Yudai Browse this author | | Yakushiji, Fumika Browse this author →KAKEN DB | | Ogura, Jiro Browse this author →KAKEN DB | | Kobayashi, Masaki Browse this author →KAKEN DB | | Shindo, Naoya Browse this author | | Ichikawa, Satoshi Browse this author →KAKEN DB | | Maenaka, Katsumi Browse this author →KAKEN DB | | Sakaitani, Masahiro Browse this author |
| Issue Date: | 4-Sep-2023 |
| Publisher: | Royal Society of Chemistry |
| Journal Title: | Chemical communications |
| Volume: | 59 |
| Issue: | 82 |
| Start Page: | 12306 |
| End Page: | 12309 |
| Publisher DOI: | 10.1039/d3cc03069e |
| Abstract: | A new compound, a derivative of 3,4,5-trimethoxy-N-phenyl benzamide bearing an 8 ''-methylimidazopyridine moiety, is found to demonstrate neuroprotective effects by preventing cell death caused by oxidative stress. The compound possesses high solubility and metabolic stability, and inhibits MPTP-induced effects in vivo, indicating high potential as a therapeutic drug for Parkinson's disease. A new compound, a derivative of 3,4,5-trimethoxy-N-phenyl benzamide bearing an 8 ''-methylimidazopyridine moiety, is found to demonstrate neuroprotective effects by preventing cell death caused by oxidative stress. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/93038 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 加藤 いづみ
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