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Arterio-jugular Differences in Serum S-100β Proteins in Patients Receiving Selective Cerebral Perfusion

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Title: Arterio-jugular Differences in Serum S-100β Proteins in Patients Receiving Selective Cerebral Perfusion
Authors: Kunihara, Takashi1 Browse this author
Shiiya, Norihiko Browse this author
Bin, Luo Browse this author
Yasuda, Keishu Browse this author
Authors(alt): 國原, 孝1
Keywords: S-100β protein
Jugular vein
Selective cerebral perfusion
Aortic arch aneurysm
Extracerebral contamination
Issue Date: 24-May-2005
Publisher: Springer-Verlag Tokyo Inc.
Journal Title: Surgery Today
Volume: 36
Issue: 1
Start Page: 6
End Page: 11
Publisher DOI: 10.1007/s00595-005-3105-5
PMID: 16378186
Abstract: Purpose The early increase in serum S100β after cardiopulmonary bypass (CPB) seems to be derived from an extracerebral source. To exclude contamination, we investigated the arterio-jugular differences in S100β levels in patients receiving selective cerebral perfusion (SCP). We also evaluated the brain-protective effect of SCP by comparing the arterial S100β levels with those in patients undergoing coronary artery bypass grafting (CABG). Methods We measured arterial and jugular venous levels of S100β in ten patients undergoing aortic arch repair with SCP for up to 12h postoperatively (SCP group). We also measured arterial levels of S100β in nine patients undergoing CABG (CPB group). Results There was no incidence of hospital death or stroke. The arterial levels of S100β in both groups were comparable and peaked just after the conclusion of CPB. The arterial and jugular venous levels of S100β were almost equivalent. The arterio-jugular differences in S100β levels were negligible, even in our SCP-group patient with postoperative delirium, who had a peak value three times higher than the other patients. Conclusions The arterio-jugular differences in S100β did not clarify the origin of their increase. Thus, measuring the jugular venous levels of S100β in patients without postoperative clinical neurological deterioration would be of little benefit. However, SCP seems to protect the brain against S100β release as effectively as conventional CPB.
Rights: The original publication is available at www.springerlink.com
Type: article (author version)
URI: http://hdl.handle.net/2115/983
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 國原 孝

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