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Arterio-jugular Differences in Serum S-100β Proteins in Patients Receiving Selective Cerebral Perfusion
|タイトル: ||Arterio-jugular Differences in Serum S-100β Proteins in Patients Receiving Selective Cerebral Perfusion|
|著者: ||Kunihara, Takashi 著作を一覧する|
Shiiya, Norihiko 著作を一覧する
Bin, Luo 著作を一覧する
Yasuda, Keishu 著作を一覧する
|キーワード: ||S-100β protein|
Selective cerebral perfusion
Aortic arch aneurysm
|発行日: ||2005年 5月24日|
|出版者: ||Springer-Verlag Tokyo Inc.|
|誌名: ||Surgery Today|
|出版社 DOI: ||10.1007/s00595-005-3105-5|
|抄録: ||Purpose The early increase in serum S100β after cardiopulmonary bypass (CPB) seems to be derived from an extracerebral source. To exclude contamination, we investigated the arterio-jugular differences in S100β levels in patients receiving selective cerebral perfusion (SCP). We also evaluated the brain-protective effect of SCP by comparing the arterial S100β levels with those in patients undergoing coronary artery bypass grafting (CABG).
Methods We measured arterial and jugular venous levels of S100β in ten patients undergoing aortic arch repair with SCP for up to 12h postoperatively (SCP group). We also measured arterial levels of S100β in nine patients undergoing CABG (CPB group).
Results There was no incidence of hospital death or stroke. The arterial levels of S100β in both groups were comparable and peaked just after the conclusion of CPB. The arterial and jugular venous levels of S100β were almost equivalent. The arterio-jugular differences in S100β levels were negligible, even in our SCP-group patient with postoperative delirium, who had a peak value three times higher than the other patients.
Conclusions The arterio-jugular differences in S100β did not clarify the origin of their increase. Thus, measuring the jugular venous levels of S100β in patients without postoperative clinical neurological deterioration would be of little benefit. However, SCP seems to protect the brain against S100β release as effectively as conventional CPB.|
|Rights: ||The original publication is available at www.springerlink.com|
|資料タイプ: ||article (author version)|
|出現コレクション:||雑誌発表論文等 (Peer-reviewed Journal Articles, etc)|
提供者: 國原 孝