Japanese Journal of Veterinary Research;Volume 2, Number 1

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HISTOPATHOLOGICAL STUDIES ON PARTURIENT HEMOGLOBINEMIA OF DAIRY COWS

FUJIMOTO, Yutaka;OHBAYASHI, Masashi;UEDA, Akira

Permalink : http://hdl.handle.net/2115/1653
JaLCDOI : 10.14943/jjvr.2.1.33

Abstract

Histopathological investigation was made of eleven cases affected with parturient hemoglobinemia. 1) Anatomically the outstanding changes found were an anemia, icterus, and edema in general. The blood was watery and dark. Especially the liver had undergone the most extensive changes. The livers of all cases were brownish-yellow or orange-yellow in colour due to fatty infiltration, sometimes slightly swollen and usually showed multiple necrotic patches. The spleen was usually congested on section of the pulp bulges and presented dark red, hemorrhagic appearance. Moreover, cloudiness of kidney, right side dilatation of the heart with subendo- and subepicardial hemorrhages, congestive edema of the lung, and enlargement and edema of the lymphnodes were found. A general diffuse catarrhal inflammation of the small intestine was recognized, but no changes were noted in the abomasum. The urinary bladder was always filled with dark red urine caused by presence of hemoglobin. 2) Histologically the most characteristic changes were observed in the liver ; namely, necrotic and necrobiotic foci in the central area of liver lobules. Fatty infiltration was general throughout the lobules in almost all of the cases and endothelial cells took fat independently. A parenchymatous degeneration, such as hyaline drop degeneration and vacuolar degeneration were conspicuous in the kidney, especially fatty infiltrations were remarkable in pars recta of HENLE'S loop and in some parts of the convoluted tubules. In some stages, hemosiderin deposits were noted in the epithelial cells of kidney. Some cases showed glomerulonephritis serosa acuta and most cases contained serous exudation in the cavity of BOWMAN'S capsule. The spleen of all cases was abundant in blood content and pulp showed high hemosiderosis. Sometimes, fibrinthrombi were recognized in the sinus of the spleen. Subendo- and subepicardial hemorrhages and congestion of the heart were recognized and especially proliferated histiocytes in the interstitium were conspicuous. Some cases showed cardiac myodegeneration, and fine granular fat deposits in the muscular fiber. Moreover, enteritis catarrhalis, lymphadenitis catarrhalis and edema were found. 3) It was concluded that the main changes of this disease are parenchymatous degeneration and secondly circulatory disturbances in addition to proliferative changes which accompanied with reactive changes in R.E.S. 4) The authors differentiated the disease of piroplasmosis, bovine hematuria (Stallrot), bacillary hemoglobinuria, leptospirosis, bacillary pyelonephritis and puerperal sepsis from parturient hemoglobinemia. 5) It is considered that some relationship exists between milk fever, ketosis, aphosphorosis and parturient hemoglobinemia. 6) This disease is considered to be a sort which is produced by disturbances of metabolism.

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