Japanese Journal of Veterinary Research;Volume 55, Number 2-3

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Roles of the hypocretin/orexins in the regulation of sleep and wakefulness

Terao, Akira;Haruyama, Takashi;Kimura, Kazuhiro

Permalink : http://hdl.handle.net/2115/32367
JaLCDOI : 10.14943/jjvr.55.2-3.75
KEYWORDS : hypocretin;orexin;narcolepsy;sleep;wakefulness

Abstract

Hypocretin/orexin is produced exclusively in the dorsal and lateral hypothalamus but its projection is widespread within the brain and plays important roles. In this paper, we review the independent discoveries of the hypocretin/orexin peptides, the neuroanatomy of this system, and the link to the sleep disorder narcolepsy that has led to the idea that this system plays a crucial role in the regulation of sleep and wakefulness.

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