Japanese Journal of Veterinary Research;Volume 5, Number 4

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BIOCHEMICAL STUDIES ON SO-CALLED OSTEOMALACIA (OSTEODYSTROPHIA FIBROSA) IN HORSES I : THE CHEMICAL COMPOSITION PER UNIT-VOLUME OF THE BONE

USHIJIMA, Jun-ichi

Permalink : http://hdl.handle.net/2115/1720
JaLCDOI : 10.14943/jjvr.5.4.185

Abstract

In this country there is a disease in horses popularly called osteomalacia which has been known for many years. It has had economic consequences for the animal husbandry industry, and of it innumerable studies have been made. The author has studied the pathochemical changes of the disease as a part of the pathological investigation of the osteodystrophic disease of domestic animals. However, the chemical analysis of the diseased bone was found to yield few data and the results are unsatisfactory because of the difficulty in evaluating the analytical data and because of the characteristic feature of the composition and the pathological condition in bone. 1. The abundance of bone salt and its high specific gravity influence the specific gravity of bone tissue. The extreme cases of bone salt reduction require much more volume to obtain the same weight as the almost normal or slight cases. Therefore any significant differences could not be found between normal and pathological conditions by the common method, i.e., by estimation of percentage composition per same weight (cf. Tables 2〜4). 2. The pathological change of the bone seems to develop without change in its volume principally as shown in the pathological finding (cf. Plate, YAMAGIWA and SATOH) and in the findings by MCLEAN and URIST. For these reasons, the author has recommended that the bone composition be evaluated per unit-volume (g/100 cc) and not by percent (%)(Tables 2 & 3), if the pathogenesis of the bone disease is studied pathochemically. Thus the slight change in the bone, having no compositional change in spite of the pathological condition as seen microscopically, can be examined biochemically by using the present method of evaluating bone compositions by per unit-volume.

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