Japanese Journal of Veterinary Research;Volume 16, Number 2-3

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STRUCTURAL AND CELLULAR CHANGES IN THE LYMPH NODES OF YOUNG MICE

HWANG, Yann-Ching;SUGIMURA, Makoto;OHTAISHI, Noriyuki;KUDO, Norio

Permalink : http://hdl.handle.net/2115/1899
JaLCDOI : 10.14943/jjvr.16.2-3.49

Abstract

In this study, the writers concentrated their attention upon histological changes of structures and cells of mouse lymph nodes. According to the difference in structural maturity, the nodes were classified as to embryonic, immature and mature types. The "light zone" was found in immature type lymph nodes. The structure suggests the possibility of independent primitive lymphoid tissue of the lymph node in contrast to the "thymus-dependent area". The appearance and regional differences of large pyroninophilic cells, plasma cells, mast cells and PAS positive cells were also studied : Large pyroninophilic cells and mast cells were found in the lymph nodes of the neonatal mice and increased in number with age. Plasma cells began to appear in lymph nodes at the end of the first week and increased in number rapidly after the end of the third week. Regional differences of these cells were clear : Large pyroninophilic cells were dominant in the mesenteric lymph nodes. Plasma cells and mast cells were predominantly found in the submandibular lymph nodes. PAS positive cells were very rare in lymph nodes of young mice.

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