Japanese Journal of Veterinary Research;Volume 16, Number 4

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ONCOGENICITY OF INFECTIOUS CANINE HEPATITIS VIRUS IN HAMSTERS

KINJO, Toshio;YANAGAWA, Ryo;FUJIMOTO, Yutaka

Permalink : http://hdl.handle.net/2115/1916
JaLCDOI : 10.14943/jjvr.16.4.145

Abstract

Two out of the four strains of infectious canine hepatitis (ICH) virus were proved to be oncogenic for newborn hamsters. When newborn hamsters were inoculated subcutaneously, with strain FD of ICH virus, tumors developed at the site of inoculation in 3 of 21 hamsters, within 153 to 174 days of inoculation. But the subcutaneous tumors soon regressed and disappeared. Strain Woc-4 produced an intraperitoneal tumor in 1 out of 13 hamsters 198 days following an intraperitoneal inoculation. This tumor developed rapidly and became very large in size (6×6×4.5 cm) and weight (77 g). The intraperitoneal tumor was easily transplantable to hamsters. After the 2nd passage we got 100% positive takes and the latent period was shortened to less than a month. Both the primary and transplanted tumors were histologically diagnosed as an undifferentiated mesenchymal tumor. Attempts to recover the ICH virus from both the primary and transplanted tumors failed, but a complement fixing antibody to the tumor antigen and to the tissue culture T antigen of the ICH virus could be demonstrated in the sera of all tumor-bearing hamsters, tested.

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