Japanese Journal of Veterinary Research;Volume 17, Number 4

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STUDIES ON ECHINOCOCCOSIS XXII : CHANGES OF SERUM TITERS IN MICE INFECTED EXPERIMENTALLY WITH E. MULTILOCULARIS

ORIHARA, Miyoji

Permalink : http://hdl.handle.net/2115/1938
JaLCDOI : 10.14943/jjvr.17.4.121

Abstract

By the complement fixation test using cystic fluid of E. multilocularis as antigens, the increases of the serum titers in company with the development of the parasite were investigated in mice infected experimentally with E. multilocularis. In the mice in which larval echinococcus normally developed, the complement fixation titer became clearly positive (1 : 16 or more) until three months elapsed after the infection. In the mice showing the considerably higher titers, corresponding animals having liver foci of extending lesion or large cysts, in which multilocular vesiculation advanced, were usually observed. Almost all the mice with the positive reaction, showed a liver-weight of 1.7 g or more. On the other hand, the mice with reduced foci, in which the larval echinococcus manifested delayed development or degeneration, showed low serum titers in the complement fixation test.

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