Japanese Journal of Veterinary Research;Volume 28, Number 1-2

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LACK OF HETEROTRANSPLANTATION OF MAREK'S DISEASE LYMPHOMA-DERIVED CELL LINES AND MD LYMPHOMA CELLS TO NUDE MICE

KODAMA, Hiroshi;MATSUMOTO, Kozo;ONUMA, Misao;MIKAMI, Takeshi;IZAWA, Hisao

Permalink : http://hdl.handle.net/2115/2184
JaLCDOI : 10.14943/jjvr.28.1-2.31

Abstract

Nude mice of BALB/c background were used for the heterotransplantation of Marek's Disease (MD) lymphoma-derived cell lines (MDCC-MSB 1,MDCC-RP 1 and MDCC-JP 2) or MD lymphoma developed in a Marek's disease virus-inoculated chicken. None out of the 57 nude mice developed tumors at the site of inoculation. These nude mice formed cytotoxic antibody against MD lymphoma-derived line cells 6-14 weeks after inoculation. The lack of heterotransplantation of cells from avian origin into nude mice is discussed in relation to the existence of natural cell-mediated immunity and of cytotoxic activity of antibody in nude mice.

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