Japanese Journal of Veterinary Research;Volume 43, Number 2

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PRELIMINARY EFFICACY TRIAL OF CYMELARSAN IN MICE ARTIFICIALLY INFECTED WITH TRYPANOSOMA BRUCEI BRUCEI ISOLATED FROM A DOG IN ZAMBIA

SYAKALIMA, Michelo;YASUDA, Jun;HASHIMOTO, Akira

Permalink : http://hdl.handle.net/2115/2514
JaLCDOI : 10.14943/jjvr.43.2.93
KEYWORDS : Trypanosomiasis;Cymelarsan (Mel Cy);mice

Abstract

An efficacy trial of Cymelarsan on a Zambian strain of Trypanosoma brucei brucei was done. Twenty-five male mice were infected intraperitoneally with 10^6 of T. b. brucei isolated from a dog. Five groups of 5 mice were treated with 0 (control), 0.25, 0.5, 1.0 and 2.0 mg/kg Cymelarsan, respectively. The target was to achieve aparasitaemia for 30 days post-treatment, euthanising those that remained parasitaemic or relapsed before then. The 0.25 and 0.5 mg/kg groups remained parasitaemic although the parasitaemic levels were reduced. The 1.0 mg/kg group had a proportion of aparasitaemic mice. However, all mice in the 2.0 mg/kg group remained aparasitaemic until day 20 when 2 mice relapsed. These resullts suggested that more than 2.0 mg/kg was required to eliminate this strain.

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