Japanese Journal of Veterinary Research;Volume 47, Number 3-4

FONT SIZE:  S M L

Immunohistochemistry for parathyroid hormone-related protein (PTHrP) in benign and malignant mammary mixed tumors of dogs with and without hypercalcemia

KONNO, Akihiro;SUKEGAWA, Akihiro;KUSANO, Michio;KARIYA, Kazuhiro;ISHIDA, Takuo;OKADA, Hiroyuki

Permalink : http://hdl.handle.net/2115/2790
JaLCDOI : 10.14943/jjvr.47.3-4.155
KEYWORDS : dog;mammary tumor;PTHrP

Abstract

We evaluated the expression of parathyroid hormone-related protein (PTHrP) by immunohistochemistry in eight benign and malignant mammary mixed tumors of dogs with (n=4) and without (n=4) hypercalcemia. Positive immunoreactive staining for PTHrP was observed in all four tumors from hypercalcemic dogs. The mammary tumors from 2 of the 4 normocalcemic dogs stained positively for PTHrP, but the numbers of immunoreactive cells and intensity of the immunoreaction were less than in the hypercalcemic dogs. In the other 2 tumors without hypercalcemia, the tissue samples were negative for PTHrP.

FULL TEXT:PDF