Japanese Journal of Veterinary Research;Volume 49, Number 1


Brain interleukin-1 is involved in blood interleukin-6 response to immobilization stress in rats

ISHIKAWA, Ikuyo;KITAMURA, Hiroshi;KIMURA, Kazuhiro;SAITO, Masayuki

Permalink : http://hdl.handle.net/2115/2863
JaLCDOI : 10.14943/jjvr.49.1.19
KEYWORDS : interleukin-1;interleukin-6;brain;stress


Interleukin (IL)-6, a cytokine for host defense responses to infection and imflammation, is known to be induced by non-invasive physical or psychological stress, too. To test possible involvement of brain IL-1 in the stress-induced IL-6 production, IL-1 mRNA expression in the hypothalamus, in parallel with blood IL-6 level, was examined in rats subjected to restriction of their movement (immobilization stress). When rats were immobilized, the hypothalamic IL-1β mRNA level was increased in 1 hr, followed by progressive rises in the serum IL-6 level. The immobilization-induced rise in serum IL-6 was mimicked by intracerebroventricular (icv) administration of IL-1β under normal conditions, whereas it was attenuated by icv injection of an IL-1 receptor antagonist. These results indicate that IL-1 in the hypothalamus plays a pivotal mediating role in the stress-induced peripheral IL-6 production.