Japanese Journal of Veterinary Research;Volume 49, Number 4

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Blood meal acquisition by ticks ; molecular advances and implications for vaccine development

MULENGA, Albert;TSUDA, Akiko;SUGIMOTO, Chihiro;ONUMA, Misao

Permalink : http://hdl.handle.net/2115/2924
JaLCDOI : 10.14943/jjvr.49.4.261
KEYWORDS : hemostasis;platelet aggregation;vasodilation;tick vaccine development

Abstract

In their quest for a blood meal, hematophagous arthropods must first defeat the host's hemostatic defense. Following injury as it occurs when hematophagous arthropods insert their proboscis into host skin to feed, the host will attempt to stop excessive blood loss through its hemostatic defense mechanism involving platelet aggregation, blood clotting and vasoconstriction. To acquire a full blood meal hematophagous arthropods inject an arsenal of bioactive enzymes which ultimately overpower the host's hemostatic defense. We have looked at a selected number of studies on the molecular biology of arthropod anti-hemostatic proteins and developed commentaries on the suitability of these molecules as target tick vaccine antigens.

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