Japanese Journal of Veterinary Research;Volume 35, Number 1

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MITOGENIC RESPONSIBILITIES OF LYMPHOCYTES IN CANINE BABESIOSIS AND THE EFFECTS OF SPLENECTOMY ON IT

KAWAMURA, Masahiro;MAEDE, Yoshimitsu;NAMIOKA, Shigeo

Permalink : http://hdl.handle.net/2115/3026
JaLCDOI : 10.14943/jjvr.35.1.1
KEYWORDS : Babesia gibsoni;canine babesiosis;canine lymphocytes;splenectomy

Abstract

In order to clarify the mechanisms of immune-responses in canine babesiosis, mitogen-induced transformation of lymphocytes from peripheral blood and its relation to parasitemia were chiefly examined in both intact and splenectomized dogs suffering from Babesia gibsoni. The lymphocyte responses to PHA-P, Con A and PWM in dogs infected with B. gibsoni were all extremely depressed as the parasite increased in their peripheral blood. The lymphocyte responses to the mitogens greatly decreased after splenectomy in both groups infected and noninfected with B. gibsoni. Furthermore, severe relapse of parasitemia appeared in the infected dogs after splenectomy. Mild parasitemia and moderate anemia were prolonged for at least 3 months with a high serum IFA titer to the parasite in splenectomized dogs.

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