Japanese Journal of Veterinary Research;Volume 8, Number 1-4

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CYTOLOGICAL STUDIES ON SIDEROCYTES IN EQUINE INFECTIOUS ANEMIA : I. MORPHOLOGICAL STUDIES ON SIDEROCYTES

SAKAMOTO, Tsukasa

Permalink : http://hdl.handle.net/2115/4667
JaLCDOI : 10.14943/jjvr.8.1-4.12

Abstract

Cytological studies on siderocytes in the blood of the jugular vein of 100 horses were carried out based upon patho-morphological investigation. The mutual relations between siderocytes, hematological changes and histological findings were investigated in detail. 1) Siderocytes were classified into siderophagous neutrophilic leucocytes, siderophagous monocytes, large siderophagocytes, small siderophagocytes and small siderophagous lymphoid cells from the morphological point of view. Each of the siderocytes was considered to originate from neutrophilic leucocytes, monocytes, reticulo-endothelial cells, type II phagocytes (AKAZAKI) and small lymphoid cells respectively. Hemosiderin substances in the siderocytes were classified morphologically into diffuse type, granular type and mixed type of the two types, and these types were considered to be characterized by cytological characteristics of siderocytes. 2) Mutual relations were recognized between the appearance of siderocytes and histological findings. In the chronic type, cases with increased small lymphoid cells in the spleen and lymph nodes manifested a comparatively higher ratio of appearance of blood-siderocytes of which the larger part was small siderophagous lymphoid cells. In all cases of the acute, subacute and relapsed types and some chronic type cases, the proliferation of reticulo-endothelial cells was recognized in tissues, while the detection of large siderophagocytes in the blood of jugular vein was rare. 3) Mutual relations were observed between the ratio of appearance and cytomorphological variety of siderocytes. In the chronic type EIA, cases with low ratio of appearance of siderocytes showed predominant appearance of siderophagous neutrophilic leucocytes and siderophagous monocytes. In accordance with the gradual increase of the ratio of appearance, however, small siderophagous lymphoid cells showed a tendency to increase and subsequently small siderophagocytes increased. In the acute and subacute types, siderophagous neutrophilic leucocytes and siderophagous monocytes provided the greater part of the siderocytes in cases with low ratio of appearance of siderocytes. A few large siderophagocytes and their degenerated forms in both types and, in addition, small siderophagocytes in the subacute type EIA participated in cases with comparatively higher ratio of appearance of siderocytes. The most of the hemosiderin in both types showed a granular form. In the relapsed type EIA, characteristics of siderocyte were various, those of the above three EIA types were observed. The ratio of appearance of siderocytes in the blood and the morphological variety of siderocytes have no mutual relations to the hemosiderosis in tissue. It can be said without doubt that blood-siderocytes are to be considered to originate not only from the tissue, but also from some sorts of cells having a special function in the blood-stream.

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