Japanese Journal of Veterinary Research;Volume 34, Number 2

FONT SIZE:  S M L

IMMUNOHISTOCHEMICAL DEMONSTRATION OF JUXTAGLOMERULAR CELLS IN THE KIDNEYS OF DOMESTIC MAMMALS AND FOWLS

KON, Yasuhiro;HASHIMOTO, Yoshiharu;KITAGAWA, Hiroshi;KUDO, Norio;MURAKAMI, Kazuo

Permalink : http://hdl.handle.net/2115/2976
JaLCDOI : 10.14943/jjvr.34.2.111
KEYWORDS : renin;juxtaglomerular cell;kidney;domestic animal

Abstract

Intrarenal distribution of renin-cotaining cells in 13 mammals and 2 fowls was immunohistochemically demonstrated. The immunoreactive cells were found as swollen epithelioid cells localized in regions of glomerular vascular poles. An overwhelming number of renin-containing cells were demonstrated mainly in the tunica media of the afferent glomerular arterioles. In 7 mammals and 1 fowl, however, a few quantities of immunoreactive cells were also notable in the same regions as the efferent glomerular arterioles, and especially in the sheep and goat, a remarkable number of immunoreactive cells were localized not only in the walls of the afferent glomerular arterioles but also in the interlobular arteries. These cells were highly variable in size and figure and were located away from the vascular poles, and they were demonstrable even in the tunica adventitia in arterioles or arteries. In the kidneys of fowls, positive cells were observed frequently in the mesangial regions along the glomerular capillaries. The present results and the relative histoplanimetrical quantification of renin-containing cells suggest the possibility that the cells, which have been regarded as the only derivative of smooth muscle cells from the tunica media of the afferent glomerular arterioles, might also be derived from cells in the tunica adventitia of the glomerular associated vessels and also the mesangial cells in the glomerulus.

FULL TEXT:PDF