Japanese Journal of Veterinary Research;Volume 34, Number 2

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PATHOMORPHOLOGICAL OBSERVATI0NS ON EPIDERMAL PAPILLOMA OF FLATFISH (LIOPSETTA OBSCURA)

FUJIMOTO, Yutaka;MADARAME, Hiroo;YOSHIDA, Hiroshi;MORIGUCHI, Ryozo;KODAMA, Hiroshi;IIZAWA, Hisao

Permalink : http://hdl.handle.net/2115/2974
JaLCDOI : 10.14943/jjvr.34.2.81
KEYWORDS : epidermal papilloma;goby;flatfish;X-cells

Abstract

Morphological investigation was carried out on 10 flatfishes (Liopsetta obscura) which were collected in Odaito, the eastern part of Hokkaido, and they were diagnosed as epidermal papilloma. Electron microscopically, the characteristics of so-called "X-cells" were clarified. They were considered as free cells which were completely different from epidermal cells and general inflammatory cells. Aggregation of fine hollow particles (ca. 30 nm) in the nucleus and particles enclosed by a double membrane with a central core in the cytoplasm were found in the X-cells. Numerous virus-like particles (ca. 100 nm) were found in the nuclei of the degenerative epithelial cells of the epidermis. Etiological relationship between epidermal papilloma and virus-like particles are not yet unknown and further investigations are needed.

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