Japanese Journal of Veterinary Research;Volume 59, Number 1

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A vaccine prepared from a non-pathogenic H5N1 influenza virus strain from the influenza virus library conferred protective immunity to chickens against the challenge with antigenically drifted highly pathogenic avian influenza virus

Asmah Abdul Samad, Rozanah;Nomura, Naoki;Tsuda, Yoshimi;Manzoor, Rashid;Kajihara, Masahiro;Tomabechi, Daisuke;Sasaki, Takashi;Kokumai, Norihide;Ohgitani, Toshiaki;Okamatsu, Masatoshi;Takada, Ayato;Sakoda, Yoshihiro;Kida, Hiroshi

Permalink : http://hdl.handle.net/2115/44862
JaLCDOI : 10.14943/jjvr.59.1.23
KEYWORDS : Antigenically drifted HPAIV;vaccine

Abstract

Inactivated influenza virus vaccine prepared from a non-pathogenic influenza virus strain A/duck/Hokkaido/Vac-1/2004 (H5N1) from the virus library conferred protective immunity to chickens against the challenge of antigenically drifted highly pathogenic avian influenza virus (HPAIV), A/whooper swan/Hokkaido/1/2008 (H5N1). The efficacy of the vaccine was comparable to that prepared from genetically modified HPAIV strain ΔRRRRK rg-A/ whooper swan/Mongolia/3/2005 (H5N1), which is more antigenically related to the challenge virus strain, in chickens.

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