Japanese Journal of Veterinary Research;Volume 35, Number 4

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ATTACHMENT OF ANTIGENIC VARIANTS OF LEPTOSPIRAS TO MOUSE FIBROBLASTS RESISTING INHIBITORY EFFECT OF ANTI-PARENT ANTISERUM

ITO, Toshihiro;YANAGAWA, Ryo

Permalink : http://hdl.handle.net/2115/8931
JaLCDOI : 10.14943/jjvr.35.4.251
KEYWORDS : Leptospira;antigenic variant;attachment;mouse fibroblasts;extracellular matrix

Abstract

Antigenic variants of Leptospira interrogans serovar canicola Moulton and hebdomadis Hebdomadis, which were isolated from the parental population by selection with monoclonal antibodies, were shown to attach to mouse skin fibroblast cells and extracellular matrix (ECM). The attachment of the variants occurred in the presence of anti-parent antiserum. Resistance of the variants to the effect of anti-parent antiserum in the attachment was in accord with their serological remoteness from the parent.

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