Japanese Journal of Veterinary Research;Volume 66 Number 4

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Prevalence of HoBi-like viruses in Japan between 2012 and 2017 based on virological methods and serology

Kozasa, Takashi;Torii, Shiho;Kameyama, Ken-ichiro;Nagai, Makoto;Isoda, Norikazu;Shiokawa, Mai;Aoki, Hiroshi;Okamatsu, Masatoshi;Sekiguchi, Hideto;Saito, Akito;Sakoda, Yoshihiro

Permalink : http://hdl.handle.net/2115/72026
JaLCDOI : 10.14943/jjvr.66.4.317
KEYWORDS : cross-reactivity;HoBi-like virus;vaccination

Abstract

The purpose of this study was to investigate the prevalence of HoBi-like viruses in Japan and evaluate the immune response induced by bovine viral diarrhea virus (BVDV) vaccines available in Japan. No HoBi-like viruses were detected by RT-PCR and virus isolation in cattle sera collected in Japan between 2012 and 2017. Nevertheless, neutralizing antibody titers against HoBi-like viruses ranged from < 2 to 4,096, demonstrating cross-reactivity to HoBi-like viruses in cattle infected (naturally or vaccinated) with BVDV-1 and BVDV-2. These results suggest that continuous vaccination with both BVDV-1 and BVDV-2 contributes to the control of HoBi-like viruses in Japan.

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