Japanese Journal of Veterinary Research;Volume 67 Number 3

FONT SIZE:  S M L

Effect of ultra low fat diet on regulatory T cells of dogs with intestinal limphangiectasia secondary to chronic enteropathy: A pilot study

Nisa, Khoirun;Ohta, Hiroshi;Yokoyama, Nozomu;Tamura, Masahiro;Nagata, Noriyuki;Sasaoka, Kazuyoshi;Dermlim, Angkhana;Leela-Arporn, Rommaneeya;Morita, Tomoya;Osuga, Tatsuyuki;Sasaki, Noboru;Morishita, Keitaro;Nakamura, Kensuke;Kagawa, Yumiko;Takiguchi, Mitsuyoshi

Permalink : http://hdl.handle.net/2115/75488
JaLCDOI : 10.14943/jjvr.67.3.221
KEYWORDS : IL-CE;Treg;ULFD

Abstract

Ultra low fat diet (ULFD) has shown a good therapeutic effect in dogs with intestinal lymphangiectasia secondary to CE (IL-CE). As we hypothesized that the mechanism of ULFD may involve the resolution of immunological impairment in IL-CE dogs, our study aimed to investigate the effect of ULFD on the circulating regulatory T cell (Treg) of IL-CE dogs. Treg frequency of pre- and post-ULFD blood samples from dogs with IL-CE (n = 3) were measured using flow cytometry. Treg frequency in IL-CE group before ULFD treatment showed lower tendency when compared to healthy control (mean±SD; 2.0±1.6% and 4.3±1.4%, respectively), and showed increased tendency after ULFD (mean±SD; 4.5±3.5%). The results suggested that ULFD might restore circulating Treg frequency of IL-CE dogs.

FULL TEXT:PDF